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Rev Bras Ginecol Obstet 2016; 38(09): 471-476
DOI: 10.1055/s-0036-1593776
Case Report
Thieme Publicações Ltda Rio de Janeiro, Brazil

Giant Condyloma (Buschke-Loewenstein Tumor) in a 16-year-old Patient: Case Report

Condiloma gigante (tumor de Buschke-Loewenstein) em uma paciente de 16 anos: relato de caso
Caetano Galvão Petrini
1   Hospital das Clínicas de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil
,
Patrícia Pereira dos Santos Melli
2   Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
,
Pedro Sérgio Magnani
2   Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
,
Laura Penna Rocha
3   General Pathology Division, Biological and Natural Sciences Institute, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil
,
Francesca Maia Faria
4   Pathology and Forensic Medicine Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
,
Geraldo Duarte
2   Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
,
Silvana Maria Quintana
2   Gynecology and Obstetrics Department, Ribeirão Preto Faculty of Medicine, USP, Ribeirão Preto, SP, Brazil
› Author Affiliations
Further Information

Publication History

16 March 2016

12 September 2016

Publication Date:
27 October 2016 (online)

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Abstract

The Buschke-Loewenstein tumor is characterized by excessive growth of verrucous lesions on the genitals and/or perianal region. It is considered benign despite the high rate of recurrence and the possibility of malignant transformation. It is commonly associated with subtypes 6 and 11 of the human papillomavirus (HPV), and host's immunity plays an important role in the development of the disease. Surgical excision is the recommended treatment in most cases. We present the case of a 16 years old female patient with extensive vulvar lesions successfully treated surgically.

Resumo

O tumor de Buschke-Loewenstein se caracteriza pelo crescimento excessivo de lesões verrucosas na região genital e/ou perianal. É considerado benigno apesar da elevada taxa de recorrência e da possibilidade de transformação maligna. Está comumente associado aos sorotipos 6 e 11 do papiloma vírus humano (HPV) e a imunidade do hospedeiro tem importante papel no desenvolvimento da doença. A excisão cirúrgica é o tratamento recomendado na maioria dos casos. Apresentamos o caso de uma paciente do sexo feminino, de 16 anos, com lesão vulvar de grande extensão tratada cirurgicamente com sucesso.

Keywords

giant condyloma - Buschke-Loewenstein tumor - human papillomavirus - HPV - surgical treatment

Palavras chave

condiloma gigante - tumor de Buschke-Loewenstein - vírus do papiloma humano - HPV - tratamento cirúrgico
 

  • References

  • 1 Steffen C. The men behind the eponym--Abraham Buschke and Ludwig Lowenstein: giant condyloma (Buschke-Loewenstein). Am J Dermatopathol 2006; 28 (6) 526-536
    CrossrefPubMedGoogle Scholar
  • 2 Schwartz RA. Verrucous carcinoma of the skin and mucosa. J Am Acad Dermatol 1995; 32 (1) 1-21 , quiz 22–24
    CrossrefPubMedGoogle Scholar
  • 3 Spinu D, Rădulescu A, Bratu O, Checheriţă IA, Ranetti AE, Mischianu D. - Giant condyloma acuminatum - Buschke-Lowenstein disease - a literature review. Chirurgia (Bucur) 2014; 109 (4) 445-450
    PubMedGoogle Scholar
  • 4 Gissmann L, deVilliers EM, zur Hausen H. Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA. Int J Cancer 1982; 29 (2) 143-146
    CrossrefPubMedGoogle Scholar
  • 5 Dianzani C, Bucci M, Pierangeli A, Calvieri S, Degener AM. Association of human papillomavirus type 11 with carcinoma of the penis. Urology 1998; 51 (6) 1046-1048
    CrossrefPubMedGoogle Scholar
  • 6 Rübben A, Beaudenon S, Favre M, Schmitz W, Spelten B, Grussendorf-Conen EI. Rearrangements of the upstream regulatory region of human papillomavirus type 6 can be found in both Buschke-Löwenstein tumours and in condylomata acuminata. J Gen Virol 1992; 73 (Pt 12): 3147-3153
    CrossrefPubMedGoogle Scholar
  • 7 Trombetta LJ, Place RJ. Giant condyloma acuminatum of the anorectum: trends in epidemiology and management: report of a case and review of the literature. Dis Colon Rectum 2001; 44 (12) 1878-1886
    CrossrefPubMedGoogle Scholar
  • 8 Suárez-Ibarrola R, Heinze A, Sánchez-Sagástegui F , et al. Giant condyloma acuminatum in the genital, perineal and perianal region in a pediatric patient. Literature review and case report. Urol Case Rep 2016; 7: 14-16
    PubMedGoogle Scholar
  • 9 Hicheri J, Jaber K, Dhaoui MR, Youssef S, Bouziani A, Doss N. Giant condyloma (Buschke-Löwenstein tumor). A case report. Acta Dermatovenerol Alp Panonica Adriat 2006; 15 (4) 181-183
    PubMedGoogle Scholar
  • 10 Niazy F, Rostami K, Motabar AR. Giant condyloma acuminatum of vulva frustrating treatment challenge. World J Plast Surg 2015; 4 (2) 159-162
    PubMedGoogle Scholar
  • 11 Bertram P, Treutner KH, Rübben A, Hauptmann S, Schumpelick V. Invasive squamous-cell carcinoma in giant anorectal condyloma (Buschke-Löwenstein tumor). Langenbecks Arch Chir 1995; 380 (2) 115-118
    PubMedGoogle Scholar
  • 12 Knoblich R, Failing Jr JF. Giant condyloma acuminatum (Buschke-Löwenstein tumor) of the rectum. Am J Clin Pathol 1967; 48 (4) 389-395
    CrossrefPubMedGoogle Scholar
  • 13 Gole GN, Shekhar T, Gole SG, Prabhala S. Successful treatment of buschke-löwenstein tumour by surgical excision alone. J Cutan Aesthet Surg 2010; 3 (3) 174-176
    CrossrefPubMedGoogle Scholar
  • 14 Martin JM, Molina I, Monteagudo C, Marti N, Lopez V, Jorda E. Buschke-Lowenstein tumor. J Dermatol Case Rep 2008; 2 (4) 60-62
    CrossrefPubMedGoogle Scholar
  • 15 Dinleyici M, Saracoglu N, Eren M , et al. Giant condyloma acuminate due to human papillomavirus type 16 in an infant successfully treated with topical imiquimod therapy. Dermatol Rep 2015; 7 (3) 6134
    PubMedGoogle Scholar
  • 16 Ganem NS, Silva BC, Nascimento MLFO , et al. [Giant condyloma acuminatum: a case report]. J Bras Doenças Sex Transm 2010; 22 (4) 222-224
    PubMedGoogle Scholar
  • 17 Coelho FMP, Mano AL, Bacellar MS, Codes LMG, Souza ELQ, Azaro Filho EM. [Buschke-Lowenstein tumor: imiquimod therapy to esphincter preservation. Case report]. Rev Bras Colo-Proctol. 2008; 28 (3) 342-346 Portuguese.
    PubMedGoogle Scholar
  • 18 Szabo G. Consequences of alcohol consumption on host defence. Alcohol Alcohol 1999; 34 (6) 830-841
    CrossrefPubMedGoogle Scholar
  • 19 Zhao H, Ye TH. [Drug abuse and infection]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006; 28 (6) 858-861 Chinese.
    PubMedGoogle Scholar
  • 20 Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum 1994; 37 (9) 950-957
    CrossrefPubMedGoogle Scholar