Hereditary Optic Neuropathies

Abstract

Hereditary optic neuropathies are a group of disorders that share similar presentation and have a genetic background. Presentation is mostly early in life with painless central vision loss that is commonly bilateral and sometimes associated with other neurological manifestations. Two common forms of hereditary optic neuropathies are Leber's hereditary optic neuropathy and the less severe dominant optic atrophy. Multiple other forms exist and may present as a monosymptomatic disease or as part of a syndrome. Although management is mostly focused on genetic counseling as well as supportive care, gene therapy has given hope for treatment, and clinical trials are ongoing.

Keywords

leber - DOA - dominant optic atrophy - hereditary optic atrophy

• References

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