Semin Thromb Hemost
DOI: 10.1055/s-0037-1601328
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA

The Clinical Relevance of Noncriteria Antiphospholipid Antibodies

Maria Laura Bertolaccini1, Giovanni Sanna2
  • 1Academic Department of Vascular Surgery, Cardiovascular Division, King's College London, United Kingdom
  • 2Louise Coote Lupus Unit, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom
Further Information

Publication History

Publication Date:
03 May 2017 (eFirst)


While lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2 glycoprotein I (anti-β2GPI) antibodies represent the best available and the most widely used tests in the investigation for antiphospholipid syndrome (APS), evidence gathered in recent years indicates that other antiphospholipid antibodies (aPL) specificities may also play a role in the syndrome. Several autoantibodies have been shown to be complexed with phospholipids other than cardiolipin, or to some domains of β2GPI, or else directed to other proteins of the coagulation cascade, and these have also been proposed to be of relevance to APS, and their diagnostic value and clinical utility are the focus of current research.