Semin Reprod Med 2017; 35(03): 304-310
DOI: 10.1055/s-0037-1603584
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Perinatal and Childhood Outcomes Associated with Infertility

Temeka Zore
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
,
Erica T. Wang
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
› Author Affiliations
Further Information

Publication History

Publication Date:
28 June 2017 (online)

Abstract

Infertility affects 11% of reproductive-age women in the United States and the number of live births from infertility treatment, both in vitro fertilization (IVF) and non-IVF fertility treatment (NIFT), continues to rise. Given this trend, the perinatal and childhood outcomes of children conceived with assisted reproduction are of critical importance. We provide a comprehensive overview of the current literature, consisting primarily of observational cohort studies focused on IVF children. The outcomes of interest include (1) perinatal outcomes of low birth weight and prematurity; (2) congenital birth defects; (3) childhood development to encompass autism spectrum disorders, development, and school functioning; (4) growth and puberty: and (5) childhood cancer. Overall, these data appear to be reassuring; however, further studies are needed to clarify the role of underlying parental infertility and to focus on NIFT conceptions. There remains a paucity of long-term data for these children as they progress to adulthood and long-term prospective registries will be the key to answering these questions.