Semin Reprod Med 2017; 35(03): 304-310
DOI: 10.1055/s-0037-1603584
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Perinatal and Childhood Outcomes Associated with Infertility

Temeka Zore1, Erica T. Wang1
  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
Further Information

Publication History

Publication Date:
28 June 2017 (online)


Infertility affects 11% of reproductive-age women in the United States and the number of live births from infertility treatment, both in vitro fertilization (IVF) and non-IVF fertility treatment (NIFT), continues to rise. Given this trend, the perinatal and childhood outcomes of children conceived with assisted reproduction are of critical importance. We provide a comprehensive overview of the current literature, consisting primarily of observational cohort studies focused on IVF children. The outcomes of interest include (1) perinatal outcomes of low birth weight and prematurity; (2) congenital birth defects; (3) childhood development to encompass autism spectrum disorders, development, and school functioning; (4) growth and puberty: and (5) childhood cancer. Overall, these data appear to be reassuring; however, further studies are needed to clarify the role of underlying parental infertility and to focus on NIFT conceptions. There remains a paucity of long-term data for these children as they progress to adulthood and long-term prospective registries will be the key to answering these questions.