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Synlett 2018; 29(15): 2046-2050
DOI: 10.1055/s-0037-1610226
DOI: 10.1055/s-0037-1610226
letter
A Domino Process for the Sustainable Synthesis of Quinazolin-4(3H)-ones with Direct Chemo- and Regioselective Bromination
Authors
This research was supported by the Research Council of the University of Tehran.
Weitere Informationen
Publikationsverlauf
Received: 03. Mai 2018
Accepted after revision: 08. Juli 2018
Publikationsdatum:
24. August 2018 (online)
Abstract
An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3H)-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K2CO3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner.
Key words
multicomponent reactions - quinazolinones - bromoacetyl bromide - regioselectivity - bromoquinazolinesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610226.
- Supporting Information (PDF)
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References and Notes
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