Synlett 2018; 29(20): 2685-2688
DOI: 10.1055/s-0037-1610323
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 1,4-Disubstituted 1H-1,2,3-Triazoles from 4-(1-Adamantyl)benzyl Azide through a 1,3-Dipolar Cycloaddition Reaction

Oussama Bencheikh le Hocine
a  Department of Chemistry, Faculty of Sciences, Université des Frères Mentouri Constantine 1, Constantine 25000, Algeria   Email: dtebbani2002@yahoo.fr
,
Dahmane Tebbani*
a  Department of Chemistry, Faculty of Sciences, Université des Frères Mentouri Constantine 1, Constantine 25000, Algeria   Email: dtebbani2002@yahoo.fr
,
b  QOPNA, Department of Chemistry, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal   Email: artur.silva@ua.pt
› Author Affiliations
Thanks are due to the University of Aveiro and FCT/MCT (Portugal) for financial support to the QOPNA Research Unit (FCT UID/QUI/00062/2013) through national founds and, where applicable, co-finance by the FEDER, within the PT2020 Partnership Agreement, as well as to the Portuguese NMR Network. Thanks are also due to the Université des Frères Mentouri Constantine 1 for a Scholarship to O.B.H.
Further Information

Publication History

Received: 14 October 2018

Accepted after revision: 15 October 2018

Publication Date:
21 November 2018 (online)


Abstract

A series of new 1,4-disubstituted 1H-1,2,3-triazole derivatives were synthesized by an efficient copper-catalyzed 1,3-dipolar cyclo­addition reaction of 4-(1-adamantyl)benzyl azide with several terminal alkynes. The copper catalyst was used to provide 1,4-disubstituted 1,2,3-triazoles regioselectively in good yields.

Supporting Information

 
  • References and Notes

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