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Thromb Haemost 1998; 79(01): 87-90
DOI: 10.1055/s-0037-1614225
Review Article
Schattauer GmbH

Factor XII Determinations in the Presence and Absence of Phospholipid Antibodies

M. J. Gallimore
1   From the Haemophilia Centre, Kent and Canterbury Hospitals NHS Trust, Canterbury, Kent, United Kingdom
,
D. W. Jones
1   From the Haemophilia Centre, Kent and Canterbury Hospitals NHS Trust, Canterbury, Kent, United Kingdom
,
M. Winter
1   From the Haemophilia Centre, Kent and Canterbury Hospitals NHS Trust, Canterbury, Kent, United Kingdom
› Author Affiliations
Further Information

Publication History

Received 10 March 1997

Accepted after resubmission 14 August 1997

Publication Date:
08 December 2017 (online)

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Summary

Factor XII (FXII) levels were determined in plasma samples from 29 normal donors, 10 patients with inherited FXII deficiency (all lupus anticoagulant [LA] negative) and 67 LA positive patients, using clotting (FXIIct), chromogenic substrate (FXIIcs) and immunochemical (FXIIag) assays. Excellent correlations were obtained in the three FXII assays with the LA negative samples and between the FXIIcs and FXIIag assays in the LA positive samples. Correlations between both the FXIIcs and FXIIag with FXIIct in the LA positive patients were poor. Of 67 LA positive samples studied, 25 (37.3%) showed lower values in the FXIIct assay; 13 (19.4%) of these patients were pseudo FXII deficient with values of FXII below the lower limit of normal.

These results indicate that a diagnosis of FXII deficiency can be made inappropriately in the presence of phospholipid antibodies and that such a diagnosis should not be made by FXIIct assay alone.

 

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