Neuronale Korrelate sexueller Funktionen unter Antidepressiva

K. Malejko; B. Abler; H. Graf

doi:10.1055/s-0037-1616421

Nervenheilkunde, Inhaltsverzeichnis

Nervenheilkunde 2016; 35(09): 575-581
DOI: 10.1055/s-0037-1616421

Universitätsklinikum Ulm

Schattauer GmbH

Neuronale Korrelate sexueller Funktionen unter Antidepressiva

Neural correlates of sexual functioning under antidepressants

K. Malejko

¹Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm

,

B. Abler

¹Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm

,

H. Graf

¹Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm

› Institutsangaben

Abstract

Zusammenfassung

Sexuelle Funktionsstörungen treten häufig in der Therapie mit monoaminerg wirksamen Antidepressiva, insbesondere unter der Einnahme von selektiven Serotoninwiederaufnahmehemmern auf und beeinträchtigen neben der Lebensqualität in erheblichem Maße die Therapieadhärenz der Betroffenen. Trotz der zunehmenden klinischen Relevanz dieser unerwünschten Arzneimittelwirkung (UAW) konnten die zentralen Mechanismen der sexuellen Dysfunktion unter antidepressiver Medikation nicht hinreichend aufgeklärt werden. In einem umfangreichen Forschungsprogramm untersuchten wir gesunde männliche Probanden mit pharmakologisch gestützter funktioneller Magnetresonanztomografie (pharmako-fMRT) und visueller erotischer Stimulation unter der Einnahme verschiedener antidepressiv wirksamer Substanzen, um die monoaminergen Wirkprinzipien auf neuronalen Korrelate sexueller Stimulation aufzuklären und stellen unsere Ergebnisse in dem folgenden Übersichtsartikel dar.

Summary

Sexual dysfunction is a major side-effect of monoaminergic antidepressant agents, e. g. the selective serotonin reuptake inhibitors (SSRIs) and substantially affects quality of life, adherence to medication and hence therapeutic success. Despite of the clinical relevance of this side-effect, the central mechanism of antidepressant-related sexual dysfunction remain unclear. Within an extensive scientific program, we investigated healthy male subjects by pharmacological functional magnet-resonance tomography (pharmaco-fMRI) under visual erotic stimulation and after intake of different classes of antidepressant agents to clarify monoaminergic principles on neural correlates of sexual behaviour. The respective results are illustrated in the following review article.

Schlüsselwörter

fMRT - SSRI - sexuelle Funktion

Keywords

fMRI - SSRIs - sexual function

Volltext

Referenzen

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