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Hamostaseologie 2009; 29(01): 44-45
DOI: 10.1055/s-0037-1616938
Original article
Schattauer GmbH

Obesity and vascular risk

H. R. Lijnen
1   Center for Molecular and Vascular Biology, KU Leuven, Belgium
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Publication History

Publication Date:
08 January 2018 (online)

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Summary

Obesity is a common disorder and a known risk factor for vascular thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems in these processes. Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity.

Keywords

Obesity - adipose tissue - thrombosis - proteolysis
 

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