Der physiologische Ablauf der Frakturheilung

Zusammenfassung

Die Knochenheilung wird durch einen komplexen, kaskadenartig ablaufenden Regenerationsmechanismus ermöglicht, der nicht mit der Bildung einer Narbe, sondern mit der vollständigen Wiederherstellung der ursprünglichen Struktur und Funktion des Knochens endet. Die Untersuchung dieses komplexen Prozesses ist nur im Tiermodell umfassend möglich, weshalb es diverse Modelle in Großund Kleintier zur Frakturheilung gibt. Eine histologische Analyse des Frakturgebiets kann den Ablauf der Knochenheilung sehr exakt und standardisiert beschreiben. Hier sollen der physiologische Ablauf der Frakturheilung in zwei gebräuchlichen Modellen (Schaf und Ratte) histologisch beschrieben und die Stärken einer histologischen Analyse herausgehoben werden.

Summary

Bone healing is enabled by a complex process, which results in scarless healing. When bone healing is successful, the original structure and function of the bone is completely restored. A thorough analysis of this complex process is practicable only in animal studies, therefore, there are many diverse models on bone healing in small and large animals.A histological analysis of the healing area delivers, if performed correctly, very exact and standardized results. This review/manuscript aims to display the physiological sequences of fracture healing in two common animal models (sheep, rat) from a histological view. The strength of histological analysis will be accentuated.

Schlüsselwörter

Frakturheilung - Histologie - Tiermodelle

Keywords

Fracture Healing - histology - animal models

• Literatur

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