Tierarztl Prax Ausg K Kleintiere Heimtiere 2014; 42(03): 157-165
DOI: 10.1055/s-0038-1623761
Originalartikel
Schattauer GmbH

Lebensqualität der Patienten nach primärer und adjuvanter Strahlentherapie in der Kleintieronkologie

Eine BesitzerumfrageQuality of life in primary and adjuvant veterinary radiation therapyAn owner survey
M. Hill
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
J. Hirschberger
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
K. Zimmermann
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
R. Dörfelt
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
,
S. Reese
2   Tierärztliche Fakultät, Veterinärwissenschaftliches Department der Ludwig-Maximilians-Universität München, Lehrstuhl für Anatomie, Histologie und Embryologie
,
M. Wergin
1   Medizinische Kleintierklinik der Ludwig-Maximilians-Universität München
› Author Affiliations
Further Information

Publication History

Eingegangen: 10 October 2013

Akzeptiert nach Revision: 05 February 2014

Publication Date:
06 January 2018 (online)

Zusammenfassung

Gegenstand und Ziel: Seit 2011 gibt es an der Universität München eine veterinärmedizinische Strahlentherapieeinrichtung. Ziel der Studie war, die Lebensqualität der behandelten Patienten und die Zufriedenheit der Tierbesitzer zu evaluieren. Material und Methoden: Allen 91 Kleintierbesitzern, die seit April 2011 in der Medizinischen Kleintierklinik München vorstellig waren und sich für eine primäre oder adjuvante Strahlentherapie ihres Tieres entschieden hatten, wurde ein Fragebogen zugesandt. Ergebnisse: Die Rücklaufquote des Fragebogens betrug 74,7% (n = 68). Nach Besitzereinschätzung führte die Strahlentherapie bei 60,3% der Tiere (n = 41) zu einer Verbesserung der Lebensqualität und bei 19,1% (n = 13) zu einer Verschlechterung. Ein Großteil der Tierbesitzer (88,2%) würde sich erneut für eine Strahlentherapie entscheiden. Schlussfolgerung: Die Verbesserung der Lebensqualität steht in Zusammenhang mit einer hohen Besitzerzufriedenheit von 83,8% (p = 0,003) und einer positiven Einstellung gegenüber der Bestrahlung (p = 0,027). Klinische Relevanz: Trotz des intensiven Kosten-und Zeitaufwands in der Radioonkologie beim Kleintier sind die Tierbesitzer der Strahlentherapie gegenüber positiv eingestellt.

Summary

Objective: External radiation therapy has been available since 2011 for small animals at the University of Munich. The aim of the study was to evaluate the quality of life of treated pets and the satisfaction of their owners. Material and methods: The questionnaire was sent to the owners of all the pets (n = 91) that had undergone primary or adjuvant radiotherapy at the Clinic of Small Animal Medicine, University of Munich, since April 2011. Results: The questionnaire was returned by 68 (74.7%) owners. According to their assessment, the quality of life improved in 41 cases (60.3%) after treatment whereas in 13 patients (19.1%) a decline was described. The majority of owners (88.2%) would have decided for repeated radiation therapy. Conclusion: Improvement of the animals’ quality of life is related to a high satisfaction (83.8%) of the owners (p = 0.003) and their positive attitude towards radiotherapy (p = 0.027). Clinical relevance: Analyses showed that for these owners, the treatment was a worthwhile therapy despite it requiring much time and money.

 
  • Literatur

  • 1 Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ. et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993; 85: 365-776.
  • 2 Asch DA, Jedrziewski MK, Christakis NA. Response rates to mail surveys published in medical journals. J Clin Epidemiol 1997; 50: 1129-1136.
  • 3 Bateman KE, Catton PA, Pennock PW, Kruth SA. 0–7–21 radiation therapy for the palliation of advanced cancer in dogs. J Vet Intern Med 1994; 08: 394-399.
  • 4 Bergmann M, Sauter-Louis C, Hirschberger J. Lebensqualitat und Lebenserwartung am malignen Lymphom erkrankter Hunde unter Chemotherapie. Eine Besitzerumfrage. Tierärztl Prax 2011; 39 (K): 229-236.
  • 5 Bowles DB, Robson MC, Galloway PE, Walker L. Owner’s perception of carboplatin in conjunction with other palliative treatments for cancer therapy. J Small Anim Pract 2010; 51: 104-112.
  • 6 Bowling A. Mode of questionnaire administration can have serious effects on data quality. J Public Health (Oxf) 2005; 27: 281-291.
  • 7 Bronden LB, Rutteman GR, Flagstad A, Teske E. Study of dog and cat owners’ perceptions of medical treatment for cancer. Vet Rec 2003; 152: 77-80.
  • 8 Chang PC, Yeh CH. Agreement between child self-report and parent proxy-report to evaluate quality of life in children with cancer. Psychooncology 2005; 14: 125-134.
  • 9 Davies DR, Wyatt KM, Jardine JE, Robertson ID, Irwin PJ. Vinblastine and prednisolone as adjunctive therapy for canine cutaneous mast cell tumors. J Am Anim Hosp Assoc 2004; 40: 124-130.
  • 10 Denneberg NA, Egenvall A. Evaluation of dog owners’ perceptions concerning radiation therapy. Acta Vet Scand 2009; 51: 19.
  • 11 Dobson JM, Scase TJ. Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. J Small Anim Pract 2007; 48: 424-431.
  • 12 Edwards P, Roberts I, Clarke M, DiGuiseppi C, Pratap S, Wentz R. et al. Methods to increase response rates to postal questionnaires. Cochrane Database Syst Rev 2007; 18: MR000008.
  • 13 Epstein AM, Hall JA, Tognetti J, Son LH, Conant Jr L. Using proxies to evaluate quality of life. Can they provide valid information about patients’ health status and satisfaction with medical care? Med Care 1989; 27: 91-98.
  • 14 Farrelly J, McEntee MC. Principles and applications of radiation therapy. Clin Tech Small Anim Pract 2003; 18: 82-87.
  • 15 Freeman LM, Rush JE, Farabaugh AE, Must A. Development and evaluation of a questionnaire for assessing health-related quality of life in dogs with cardiac disease. J Am Vet Med Assoc 2005; 226: 1864-1868.
  • 16 Hartmann K, Kuffer M. Karnofsky’s score modified for cats. Eur J Med Res 1998; 03: 95-98.
  • 17 Hillers KR, Lana SE, Fuller CR, LaRue SM. Effects of palliative radiation therapy on nonsplenic hemangiosarcoma in dogs. J Am Anim Hosp Assoc 2007; 43: 187-192.
  • 18 Hirschberger J. Prinzipien der Chemotherapie. In: Kleintieronkologie: Diagnose und Therapie von Tumorerkrankungen bei Hund und Katze. Kessler M. Hrsg. Stuttgart: Enke; 2013: 97-132.
  • 19 Karnofsky DA, Burchenal JH. In: Evaluation of Chemotherapeutic Agents. Macleod CM. ed. Columbia: Univ Press; 1949: 196.
  • 20 Ladue T, Klein MK. Veterinary Radiation Therapy Oncology Group. Toxicity criteria of the veterinary radiation therapy oncology group. Vet Radiol Ultrasound 2001; 42: 475-476.
  • 21 LaRue S, Gillette E. Radiation Therapy. In: Withrow & MacEwen’s Small Animal Clinical Oncology. Withrow SJ, Vail DM. eds. St. Louis: Saunders; 2007: 193-211.
  • 22 Leach TN, Childress MO, Greene SN, Mohamed AS, Moore GE, Schrempp DR. et al. Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Vet Comp Oncol 2012; 10: 102-112.
  • 23 McEntee MC. Veterinary radiation therapy: review and current state of the art. J Am Anim Hosp Assoc 2006; 42: 94-109.
  • 24 McMillan FD. Quality of life in animals. J Am Vet Med Assoc 2000; 216: 1904-1910.
  • 25 Mellanby RJ, Herrtage ME, Dobson JM. Owners’ assessments of their dog’s quality of life during palliative chemotherapy for lymphoma. J Small Anim Pract 2003; 44: 100-103.
  • 26 Pajonk F, Riedisser A, Henke M, McBride WH, Fiebich B. The effects of tea extracts on proinflammatory signaling. BMC Med 2006; 04: 28.
  • 27 Parker C, Dewey M. Assessing research outcomes by postal questionnaire with telephone follow-up. TOTAL Study Group. Trial of Occupational Therapy and Leisure. Int J Epidemiol 2000; 29: 1065-1069.
  • 28 Theunissen NC, Vogels TG, Koopman HM, Verrips GH, Zwinderman KA, Verloove-Vanhorick SP. et al. The proxy problem: child report versus parent report in health-related quality of life research. Qual Life Res 1998; 07: 387-397.
  • 29 Tzannes S, Hammond MF, Murphy S, Sparkes A, Blackwood L. Owners’ perception of their cats’ quality of life during COP chemotherapy for lymphoma. J Feline Med Surg 2008; 10: 73-81.
  • 30 Weinberger M, Oddone EZ, Samsa GP, Landsman PB. Are health-related quality-of-life measures affected by the mode of administration?. J Clin Epidemiol 1996; 49: 135-140.
  • 31 Welle MM, Bley CR, Howard J, Rufenacht S. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 2008; 19: 321-339.
  • 32 Wojciechowska JI, Hewson CJ. Quality-of-life assessment in pet dogs. J Am Vet Med Assoc 2005; 226: 722-728.
  • 33 Wojciechowska JI, Hewson CJ, Stryhn H, Guy NC, Patronek GJ, Timmons V. Development of a discriminative questionnaire to assess nonphysical aspects of quality of life of dogs. Am J Vet Res 2005; 66: 1453-1460.
  • 34 Wojciechowska JI, Hewson CJ, Stryhn H, Guy NC, Patronek GJ, Timmons V. Evaluation of a questionnaire regarding nonphysical aspects of quality of life in sick and healthy dogs. Am J Vet Res 2005; 66: 1461-1467.
  • 35 Yeates J, Main D. Assessment of companion animal quality of life in veterinary practice and research. J Small Anim Pract 2009; 50: 274-281.
  • 36 Zenker I, Meichner K, Steinle K, Kessler M, Hirschberger J. Thirteen-week dose-intensifying simultaneous combination chemotherapy protocol for malignant lymphoma in dogs. Vet Rec 2010; 167: 744-748.