CC BY-NC-ND 4.0 · Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery 2021; 40(03): e253-e256
DOI: 10.1055/s-0038-1625962
Review Article | Artigo de Revisão

Brain Tumor Heterogeneity

Heterogeneidade dos tumores cerebrais
Telmo Augusto Barba Belsuzarri
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
Maick Willen Fernandes Neves
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
Otávio Augusto da Costa
2   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil
,
Diego Alves Soares
2   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, São Paulo, Brazil
,
Fernando Antônio de Melo Filho
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
Mariana Mazzuia Guimarães
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
Tiago Fernandes Gonçales
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
Wolnei Marques Zeviani
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
,
João Flávio Mattos Araújo
1   Department of Neurosurgery, Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, Campinas, SP, Brazil
› Author Affiliations

Abstract

Tumor heterogeneity is the concept that different tumor cells provide distinct biomorphological lesions, gene expressions, proliferation, microenvironment and graduated capacity of metastatic lesions. Brain tumor heterogeneity has been recently discussed about the interesting interaction of chronic inflammation, microenvironment, epigenetics and glioma steam cells. Brain tumors remain a challenge with regards to medication and disease, due to the lack of treatment options and unsatisfactory results. These results might be the result of the brain tumor heterogeneity and its multiple resistance mechanisms to chemo and radiotherapy.

Resumo

Heterogeneidade tumoral significa que diferentes células tumorais levam a lesões morfológicas e fenotípicas distintas, com diferentes morfologias celulares, expressão gênica, metabolismo, microambiente, proliferação e possibilidade de lesões metastáticas. A heterogeneidade dos tumores cerebrais malignos tem sido o foco essencial de pesquisas recentes devido às interações notáveis entre genética, epigenética, microambiente e células-tronco glioma, todas mediadas por inflamação crônica. Tumores cerebrais ainda são um desafio no que tange a medicação e doença, podendo, com a carência de opções terapêuticas aliada a resultados insatisfatórios, ocorrer devido à heterogeneidade do tumor e seus múltiplos mecanismos de resistência à quimio e radioterapia. Foi realizada uma revisão da literatura na base de dados PubMed usando os termos: brain tumor, heterogeneity, epigenetic, microenvironment, e glioma stem cells.



Publication History

Received: 22 October 2017

Accepted: 18 December 2017

Article published online:
13 March 2018

© 2018. Sociedade Brasileira de Neurocirurgia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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