Methods Inf Med 1991; 30(04): 256-267
DOI: 10.1055/s-0038-1634847
Original Article
Schattauer GmbH

Probabilistic Diagnosis Using a Reformulation of the INTERNIST-1/QMR Knowledge Base

II. Evaluation of Diagnostic Performance
B. Middleton
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
A. M. Shwe
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
E. D. Heckerman
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
M. Henrion
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
J. E. Horvitz
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
P. H. Lehmann
1   Section on Medical Informatics, Stanford University, Stanford, CA
,
F. G. Cooper
1   Section on Medical Informatics, Stanford University, Stanford, CA
› Author Affiliations
Further Information

Publication History

Publication Date:
07 February 2018 (online)

Abstract

We have developed a probabilistic reformulation of the Quick Medical Reference (QMR) system. In Part I of this two-part series, we described a two-level, multiply connected belief-network representation of the QMR knowledge base and a simulation algorithm to perform probabilistic inference on the reformulated knowledge base. In Part II of this series, we report on an evaluation of the probabilistic QMR, in which we compare the performance of QMR to that of our probabilistic system on cases abstracted from continuing medical education materials from Scientific American Medicine. In addition, we analyze empirically several components of the probabilistic model and simulation algorithm.

* QMR is a registered trademark of the University of Pittsburgh.


® I We are currently using the INTERNIST-I KB (circa 1986). rather than the more recent QMR KB. These two KBs are quite similar. to the extent that the methods in this paper can be applied to the latter KB as well. For simplicity. where the distinction between the INTERNIST-J KB and QMR KB is inconsequential. we will refer to the INTERNIST-I KB as the QMR KB.