Endoscopy 2018; 50(04): S36
DOI: 10.1055/s-0038-1637133
ESGE Days 2018 oral presentations
20.04.2018 – Esophagus: SCC, Barrett's, GERD
Georg Thieme Verlag KG Stuttgart · New York

OPTICAL ENHANCEMENT TECHNOLOGY AS A DIAGNOSTIC TOOL IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

T Thomaidis
1   University Hospital Mainz, Mainz, Germany
,
F Rahman
1   University Hospital Mainz, Mainz, Germany
,
F Thieringer
1   University Hospital Mainz, Mainz, Germany
,
G Tontini
2   IRCCS Policlinico San Donato, Gastroenterology & Digestive Endoscopy Unit, Milan, Italy
,
K Mönkenmüller
3   Helios Frankenwaldklinik, Gastroenterology Department, Kronach, Germany
,
I Sauid
4   Dudley Group Hospitals, Gastroenterology Department, Dudley, United Kingdom
5   Birmingham City University, Birmingham, United Kingdom
,
P Galle
1   University Hospital Mainz, Mainz, Germany
,
H Neumann
1   University Hospital Mainz, Mainz, Germany
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

Optical Enhancement technology (OE) combines optical filters with digital postprocessing for enhanced visualization of surface and vascular changes. This is the first study assessing the new technology for diagnosis of gastroesophageal reflux disease (GERD). Aim of this study is to investigate the utility of OE in improving the diagnosis of patients with GERD.

Methods:

Patients with GERD and controls were prospectively included. The distal esophagus was examined in all quadrants with high definition white-light endoscopy (HD-WLE) followed by OE. Biopsies were taken for histopathological analysis. Features seen only by OE were compared between controls and patients with GERD.

Results:

100 areas were evaluated. 56% of patients had diagnosis of GERD, whereas mean age of patients was 53 years (range 27 – 89 years); 60% were female. Patients diagnosed with GERD showed significantly more often tortuosity (p = 0.042), dilation (p = 0.0003), and increased number (p = 0.001) of intrapapillary capillary loops (IPCLs) in comparison to controls. In addition, increased vascularity and mucosal breaks were significantly more often found in patients with GERD as compared to controls (p < 0.05). On multivariate analysis, increased number and dilation of IPCL were the best predictors of GERD.

Conclusions:

The newly introduced OE technology shows promising results in improving the diagnosis of GERD. Further prospective multicentral trials are necessary for the verification of OE's diagnostic utility in patients with GERD.