Endoscopy 2018; 50(04): S154
DOI: 10.1055/s-0038-1637497
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

FREQUENCY OF CELIAC DISEASE IN PATIENTES WHO COMBINED LOW PLASMA IRON AND VITAMIN B12 AND EVALUATION WITH MAGNIFIED UPPER GASTROINTESTINAL ENDOSCOPY

Ö Burcak Binicier
1   Tepecik Education and Research Hospital, Gastroenterology, Izmir, Turkey
,
S Akay
2   Izmir Atatürk Education and Research Hospital, Internal Medicine, Izmir, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

Celiac disease (CD) is characterized with malabsorption. The gold standard for the diagnosis is histopatological findings confirmed with the serologic tests. Herein we aimed to study the frequency of CD and evaluate whether the magnified endoscopy and magnified FICE (Fujinon Intelligence Color Enhancement) techniques do contribute the diagnosis in patients with combined decreased serum iron and vitamin B12 levels.

Methods:

We evaluated 50 patients (10 men and 40 women) who have combined low serum iron and vitamin B12 levels. All the patients had undergone to upper gastrointestinal system endoscopy by the same endoscopist. The second segment of duodenum was evaluated with magnified endoscopy and magnified FICE techniques. Biopsy specimens from duodenum, antrum and corpus were evaluated by the same pathologist. Speciemens which are diagnosed as CD were classified according to Modified Marsh-Oberhuber criteria.

Results:

10 of 50 patients (% 20) were diagnosed as CD. The average age was 41 ± 11 years (20 – 67 years). All of the Ced patients had positive serology for tissue transglutaminase IgA antibody and the diagnosis was approved with the biopsy. There were no difference between hemoglobin, hematocrit, serum iron, ferritin, vitamin B12 and folic acid levels of the CD and non-CD groups. % 30 of CD diagnosed patients had typical CD symptoms. Six of 10 patients who diagnosed as CD had typical endoscopic images under white colored endoscopy such as erosion, nodular areas, mosaic pattern, irregularity of the mucosa consistent with CD. They also evaluated with magnified FICE endoscopy and all of the 10 patients (% 100) showed villous irregularity, partial villous atrophy or total villous atrophy consistent with CD.

Conclusions:

In addition to conventional white colored upper gastrointestinal system endoscopy practice use of magnified FICE endoscopy allows us to differentiate mucosal abnormalities of the duodenum and minimize the false negative results that have normal mucosal findings with conventional endoscopy.