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DOI: 10.1055/s-0038-1637545
ASSOCIATION BETWEEN METABOLIC RISK FACTORS AND COLORECTAL POLYPS
Publication History
Publication Date:
27 March 2018 (online)
Aims:
Our aim was to identify if the presence of metabolic risk factors should be consider for assessing the risk of developing colorectal cancer (CRC) and if these risk factors are to be consider when starting CRC screening programme.
Methods:
The study included patients admitted in the Gastroenterology Department of Emergency County Hospital Oradea in 2016, who underwent colonoscopy and who were found to have colorectal polyps. We evaluated the presence of metabolic risk factors: non-alcoholic fatty liver (NAFLD), diabetes mellitus, obesity, hypercholesterolemia, hypertriglyceridemia and hypertension. We excluded patients with current or past malignancy, regardless of location, those with acute or chronic liver disease (other than NAFLD) and those with inflammatory bowel disease or other type of colitis.
Results:
We included 143 patients, from which 121 patients had biopsies or polypectomy performed. 80 patients had adenomas and the rest had hyperplastic polyps. In the entire group, the prevalence of NAFLD (72,8%), diabetes (35,7%), hypercholesterolemia (39,8%), hypertriglyceridemia (34,3%) and hypertension (46,9%) were higher than those found in the general population. Among those with adenomas there was a statistically significantly association beetween the presence of metabolic risk factors and the risk of having displasia on the polyp biopsy – NAFLD (p = 0,001; OR 4,54; 95% CI 1,73 – 11,89), diabetes (p = 0,02; OR 2,97; 95% CI 1,11 – 7,94), hypercholesterolemia (p = 0,002; OR 4,66; 95% CI; 1,62 – 13,39), hypertriglyceridemia (p = 0,03; OR 3; 95% CI; 1,03 – 8,67) and hypertension (p = 0,01; OR 3,12; 95% CI 1,24 – 7,87).
Conclusions:
NAFLD and metabolic risk factors like diabetes mellitus, dyslipidemia and hypertension have been shown to be more frequent in patients with colorectal polyps. Patients with metabolic risk factors seems to have more severe histological changes than those without these risk factors and one should take into account the inclusion of those risk factors in establishing the risk for developing CRC and when deciding to start CRC screening programme.