Endoscopy 2018; 50(04): S174
DOI: 10.1055/s-0038-1637567
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

THE SHORT INFLAMMATORY BOWEL DISEASE QUESTIONNAIRE CANNOT ACCURATELY DETECT SIGNIFICANT ONGOING MUCOSAL INFLAMMATION IN ULCERATIVE COLITIS PATIENTS IN CLINICAL REMISSION

T Voiosu
1   UMF Carol Davila School of Medicine, Internal Medicine Department, Bucharest, Romania
2   Colentina Clinical Hospital, Gastroenterology Division, Bucharest, Romania
,
A Benguş
2   Colentina Clinical Hospital, Gastroenterology Division, Bucharest, Romania
,
M Ioniţă
2   Colentina Clinical Hospital, Gastroenterology Division, Bucharest, Romania
,
A Voiosu
2   Colentina Clinical Hospital, Gastroenterology Division, Bucharest, Romania
,
B Mateescu
1   UMF Carol Davila School of Medicine, Internal Medicine Department, Bucharest, Romania
2   Colentina Clinical Hospital, Gastroenterology Division, Bucharest, Romania
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

Patient-reported outcomes such as health-related quality of life questionnaires have become useful tools in assessing disease activity and response to treatment in inflammatory bowel disease patients. We aimed to assess whether the Short Inflammatory Bowel Disease Questionnaire (SIBDQ) could be used to detect on-going severe mucosal inflammation among ulcerative colitis patients in clinical remission.

Methods:

We conducted a subgroup analysis of data collected from UC patients enrolled in an ongoing prospective cohort study of IBD patients. Clinical, biological and endoscopic data (including the Mayo endoscopic subscore) as well as SIBDQ scores were available at multiple time-points for the patients. Disease activity was assessed using the Mayo score, with a score of 3 or less signifying clinical remission. We assessed the diagnostic yield of SIBDQ in detecting on-going mucosal inflammation at two different thresholds – Mayo endoscopic subscore of ≥1 and 2 respectively using receiver operating characteristic (ROC) curve analysis.

Results:

Data from 103 ulcerative colitis patients totaling 220 study visits was available for review and 102 timepoints when patients were in clinical remission were included in the final analysis. Endoscopic examination showed a Mayo endoscopic subscore of 0 in 44 cases (43.6%) and a subscore of 1 in another 44, with 14 (13.7%) and 2 (3.9%) patients having subscores of 2 and 3 respectively. Mean SIBDQ score for these patients was 55 (SD-10.5). There was no significant difference in mean SIBDQ scores for patients with our without active mucosal inflammation at endoscopy defined as a Mayo subscore of ≥1 (55 ± 9.5 vs. 55 ± 11, p = 0.87) or ≥2 (55 ± 11 vs. 56 ± 5, p = 0.58) with AUROCs of 0.51 (95% CI 0.39 – 0.63) and 0.5 (95% CI 0.38 – 0.62) respectively.

Conclusions:

The SIBDQ score has low sensitivity in detecting endoscopic mucosal inflammation in ulcerative colitis patients in clinical remission.