Endoscopy 2018; 50(04): S179
DOI: 10.1055/s-0038-1637583
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

COMPARATIVE STUDY OF RADIATION PROCTITIS IN PROSTATE CANCER TREATED WITH CYBERKNIFE THERAPY AND CONVENTIONAL RADIOTHERAPY

EK Kang
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
HJ Kim
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
JW Choi
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
HC Jung
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
SB Ji
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
CM Lee
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
HC Jo
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
HJ Kim
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
TH Kim
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
WT Jung
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
OJ Lee
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
,
CY Ha
1   Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Department of Internal Medicine, Jinju, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

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Aims:

Radiation proctitis (RP) is a common complication after pelvic radiation therapy (RT). RT could cause damage to the around tissue depending on the total dose of radiation or the therapeutic range of radiation. CyberKnife is known to have less effects on surrounding tissues and low complication rate compared with conventional RT. In this study, we evaluated the effects of CyberKnife and conventional RT in prostate cancer patients with RP.

Methods:

This study was a retrospective study. From January 2010 to July 2017, total 277 patients who underwent RT with prostate cancer were included. Patients were divided to conventional RT group and CyberKnife group. The length of proctitis was measured distance from anal verge to proctitis lesion.

Results:

Of total patients, 178 (64.3%) patients were treated with conventional RT and others were treated with CyberKnife. RP were occurred more often in CyberKnife group (17%, 17/99) than conventional group (7.9%, 14/178). The mean age differences of two groups were not significant. The median number of RT (32 vs. 7), duration of treatment (48 vs. 9 days) and total radiation dose (7030 vs. 3750 cGy) of conventional RT group were significantly higher than CyberKnife group (p < 0.001). The lesion length of conventional RT group also longer than CyberKnife group (10.8 ± 6.3 vs. 6.6 ± 1.7 cm, p = 0.02). But, the rate of RP patients who required endoscopic hemostasis was lower in conventional RT group significantly. (28.6% vs. 64.7%, p = 0.045).

Conclusions:

The conventional RT group had more longer length of RP and higher radiation exposure than CyberKnife group. But, severe RP which need endoscopic hemostasis were occurred more often in CyberKnife group significantly. Therefore, more attentions were needed patients with RP after CyberKnife treatment.