Endoscopy 2018; 50(04): S181
DOI: 10.1055/s-0038-1637590
ESGE Days 2018 ePosters
Georg Thieme Verlag KG Stuttgart · New York

P53 IMMUNOEXPRESSION IN HIGH DEGREE DYSPLASIA COLON ADENOMAS FROM CHOLECYSTECTOMIZED CUBAN PATIENTS AND WITH CHOLELITHIASIS

FN Piñol Jiménez
1   National Center Minimal Access Surgery, La Habana, Cuba
,
L González Fabian
1   National Center Minimal Access Surgery, La Habana, Cuba
,
M Morera
1   National Center Minimal Access Surgery, La Habana, Cuba
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

Also available at
 

Aims:

The progression of adenoma to adenocarcinoma is a result of inherited or acquired genetic factors present in intestinal cells.

The aim of this research was to determine p53 immunoexpression in high degree dysplasia colon adenomas from Cuban patients who had been cholecystectomized and with cholelithiasis.

Methods:

A cross-sectional descriptive study was performed at the Institute of Gastroenterology from May 2013 to May 2015 in sixteen adult patients with a history of cholecystectomy and with cholelithiasis, with colonoscopic polyp and histological high degree dysplasia adenoma diagnosis. Descriptive statistical, Chi-squared and Fisher's Exact Probability tests were performed.

Results:

In both groups p53 immunoexpression was present in 62,5% of patients with high degree dysplasia adenomas and there was a high frequency (75,0%) of fecal occult blood positivity. The combined analysis of occult blood and p53 immunoexpression in both groups showed that these patients have a high positivity frequency in both tests regardless of when they were cholecystectomized and of the number of stones.

Conclusions:

The results of this study performed for the first time in Cuban cholecystectomized patients and with cholelithiasis shows p53 immunoexpression predisposition in high degree dysplasia colon adenomas indicating that both groups may be at risk and deserve a broader investigation.