CC BY-NC-ND 4.0 · Laryngorhinootologie 2018; 97(S 02): S324-S325
DOI: 10.1055/s-0038-1640843
Abstracts
Rhinologie: Rhinology

Association between chronic rhinosinusitis and asthma status holds in patients with and without polyps

RA Gaudin
1   Mund-, Kiefer- und Plastische Gesichtschirurgie, Berlin
,
L Hoehle
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
K Phillips
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
D Caradonna
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
S Gray
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
A Sedaghat
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
› Author Affiliations
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Background:

We have previously found that chronic rhinosinusitis (CRS) disease burden is associated with worse pulmonary status in asthmatic CRS patients.

Objective:

To determine whether the association between CRS disease burden and asthma status varies depending on whether the patients have polyps or not.

Methods:

We prospectively recruited 80 CRS patients with nasal polyps (CRSwNP) and 80 CRS patients without nasal polyps (CRSsNP). CRS symptom burden was measured using the 22-item Sinonasal Outcome Test (SNOT-22). Asthma status was determined using the Asthma Control Test (ACT) and the number of asthma-related oral corticosteroid courses taken in the last year.

Results:

The mean SNOT-22 scores of CRSwNP and CRSsNP were 41.6 (SD: 25.6) and 46.3 (24.2), respectively. The mean ACT scores of CRSwNP and CRSsNP were 19.9 (SD: 4.9) and 18.5 (6.0), respectively. The mean numbers of asthma-related oral corticosteroids courses taken by CRSwNP and CRSsNP were 1.1 (SD: 1.9) and 1.6 (2.1), respectively. In CRSwNP, SNOT-22 was significantly associated with ACT score (linear regression coefficient [β]=-0.08, 95%CI: -0.13 – -0.04, p < 0.001) and asthma-related oral corticosteroids usage (relative rate [RR]= 1.02, 1.01 – 1.04, p = 0.026). In CRSsNP, SNOT-22 was significantly associated with ACT score (β=-0.14, 95%CI: -0.22 – -0.07, p = 0.001) and asthma-related oral corticosteroids usage (RR = 1.02, 1.01 – 1.04, p = 0.021).

Conclusion:

The association between CRS disease burden and worsening asthma status is true for patients with polyps and without polyps.



Publication History

Publication Date:
18 April 2018 (online)

© 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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