Open Access
CC BY-NC-ND 4.0 · Laryngorhinootologie 2018; 97(S 02): S324-S325
DOI: 10.1055/s-0038-1640843
Abstracts
Rhinologie: Rhinology

Association between chronic rhinosinusitis and asthma status holds in patients with and without polyps

RA Gaudin
1   Mund-, Kiefer- und Plastische Gesichtschirurgie, Berlin
,
L Hoehle
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
K Phillips
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
D Caradonna
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
S Gray
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
,
A Sedaghat
2   Department of Otolaryngology, Harvard Medical School, Boston, USA
› Author Affiliations
› Further Information
Also available ateRef
 
 

    Background:

    We have previously found that chronic rhinosinusitis (CRS) disease burden is associated with worse pulmonary status in asthmatic CRS patients.

    Objective:

    To determine whether the association between CRS disease burden and asthma status varies depending on whether the patients have polyps or not.

    Methods:

    We prospectively recruited 80 CRS patients with nasal polyps (CRSwNP) and 80 CRS patients without nasal polyps (CRSsNP). CRS symptom burden was measured using the 22-item Sinonasal Outcome Test (SNOT-22). Asthma status was determined using the Asthma Control Test (ACT) and the number of asthma-related oral corticosteroid courses taken in the last year.

    Results:

    The mean SNOT-22 scores of CRSwNP and CRSsNP were 41.6 (SD: 25.6) and 46.3 (24.2), respectively. The mean ACT scores of CRSwNP and CRSsNP were 19.9 (SD: 4.9) and 18.5 (6.0), respectively. The mean numbers of asthma-related oral corticosteroids courses taken by CRSwNP and CRSsNP were 1.1 (SD: 1.9) and 1.6 (2.1), respectively. In CRSwNP, SNOT-22 was significantly associated with ACT score (linear regression coefficient [β]=-0.08, 95%CI: -0.13 – -0.04, p < 0.001) and asthma-related oral corticosteroids usage (relative rate [RR]= 1.02, 1.01 – 1.04, p = 0.026). In CRSsNP, SNOT-22 was significantly associated with ACT score (β=-0.14, 95%CI: -0.22 – -0.07, p = 0.001) and asthma-related oral corticosteroids usage (RR = 1.02, 1.01 – 1.04, p = 0.021).

    Conclusion:

    The association between CRS disease burden and worsening asthma status is true for patients with polyps and without polyps.


     

    No conflict of interest has been declared by the author(s).

    Dr. med. Robert Andre Gaudin
    Klinik für Mund-, Kiefer- und Plastische Gesichtsc,
    Hindenburgdamm 30, 12200,
    Berlin

    Publication History

    Publication Date:
    18 April 2018 (online)

    © 2018. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

    Georg Thieme Verlag KG
    Stuttgart · New York