Function and Regulation of the β₃ Integrins in Hemostasis and Vascular Biology

• References

• 1 Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992; 69: 11-25
• 2 Yang JT, Rayburn H, Hynes RO. Embryonic mesodermal defects in alpha(5) integrin-deficient mice. Development 1993; 119: 1093-1105
• 3 Fitzgerald LA, Steiner B, Rail Jr SC, Lo SS, Phillips DR. Protein sequence of endothelial glycoprotein Ilia derived from a cDNA clone. Identity with platelet glycoprotein Ilia and similarity to “integrin”. J Biol Chem 1987; 262: 3936-3939
• 4 Fitzgerald LA, Poncz M, Steiner B, Rail Jr SC, Bennett JS, Phillips DR. Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein lib. Biochemistry 1987; 26: 8158-8165
• 5 Haas TA, Plow EF. Integrin ligand interactions- A year in review. Current Opinion in Cell Biology 1994; 6: 656-662
• 6 Smith JW, Piotrowicz RS, Mathis D. A mechanism for divalent cation regulation of b₃-integrins. J Biol Chem 1994; 269: 960-967
• 7 D’Souza SE, Haas TA, Piotrowicz RS, Byers-Ward V, McGrath DE, Soule HR, Ciemiewski C, Plow EF, Smith JW. Ligand and cation binding are dual functions of a discrete segment of the integrin p₃ subunit: Cation displacement is involved in ligand binding. Cell 1994; 79: 659-667
• 8 Calvete JJ. Clues for understanding the structure and function of a prototypic human integrin: The platelet glycoprotein Ilb/IIIa complex. Thromb Haemost 1994; 72: 1-15
• 9 Rocco M, Spotomo B, Hantgan RR. Modeling of the α_Ilbβ₃ integrin solution conformation. Protein Sci 1993; 2: 2154-2166
• 10 Felding-Habermann B, Cheresh DA. Vitronectin and its receptors. Current Opinion in Cell Biology 1993; 5: 864-868
• 11 Kaplan KB, Bibbins KB, Swedlow JR, Amaud M, Morgan DO, Varmus HE. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527. EMBO J 1994; 13: 4745-4756
• 12 Stupack DG, Shen C, Wilkins JA. Induction of avb₃ integrin-mediated attachment to extracellular matrix in β₁ integrin (CD29)-negative B cell lines. Exp Cell Res 1992; 203: 443-448
• 13 Coller BS, Cheresh DA, Asch E, Seligsohn U. Platelet vitronectin receptor expression differentiates Iraqui-Jewish from Arab patients with Glanzmann thrombasthenia in Israel. Blood 1991; 77: 75-83
• 14 Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-938
• 15 Defilippi P, Silengo L, Tarone G. Regulation of adhesion receptor expression in endotheial cells. Curr Topics Micro Immunol 1993; 184: 87-98
• 16 Swerlick RA, Brown EJ, xu Y, Lee KH, Manos S, Lawley TJ. Expression and modulation of the vitronectin recpetoron human dermal microvascular endothelial cells. J Invest Dermatol 1992; 99: 715-772
• 17 Klein S, Giancotti F, Presta M, Albelda SM, Buck CA, Rifkin DB. Basic fibroblast growth-factor modulates integrin expression in microvascular endothelial cells. Molec Biol Cell 1993; 4: 973-982
• 18 Conforti G, Dominguez-Jiminez C, Zanetti A, Gimbrone MA, Cremona O, Marchisio PC, Dejana E. Human endothelial cells express integrin receptors on the luminal aspect of their membrane. Blood 1992; 80: 437-446
• 19 Sriramarao P, Mendler M, Bourdon MA. Endothelial cell attachment and spreading on human tenascin is mediated by α₂β₁ and α_vβ₃ integrins. J Cell Sci 1993; 105: 1001-1012
• 20 Beacham DA, Wise RJ, Turci SM, Handin RI. Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. J Biol Chem 1992; 267: 3409-3415
• 21 Cherny RC, Honan MA, Thiagarajan P. Site-directed mutagenesis of the arginine-glycine-aspartic acid in vitronectin abolishes cell adhesion. J Biol Chem 1993; 268: 9725-9729
• 22 Farrell DH, Thiagarajan P, Chung DW, Davie EW. Role of fibrinogen α and β chain sites in platelet aggregation. Proc Natl Acad Sci USA 1992; 89: 10729-10732
• 23 Farrell DH, Thiagarajan P. Binding of recombinant fibrinogen mutants to platelets. J Biol Chem 1994; 269: 226-231
• 24 Ugarova TP, Budzynski AZ, Shattil SJ, Ruggeri ZM, Ginsberg MH, Plow EF. Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa. J Biol Chem 1993; 268: 21080-21087
• 25 Denis C, Williams JA, Lu X, Meyer D, Baruch D. Solid-phase von Willebrand factor contains a conformationally active RGD motif that mediates endothelial cell adhesion through the α_vβ₃ receptor. Blood 1993; 82: 3622-3630
• 26 Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF. Regulation of glycoprotein Ilb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J Biol Chem 1992; 267: 18424-18431
• 27 Zanetti A, Conforti G, Hess S, Martin-Padura I, Ghibaudi E, Preissner KT, Dejana E. Clustering of vitronectin and RGD peptides on microspheres leads to engagement of integrins on the luminal aspect of endothelial cell membrane. Blood 1994; 84: 1116-1123
• 28 Savage B, Shattil SJ, Ruggeri ZM. Modulation of platelet function through adhesion receptors. A dual role for glycoprotein Ilb-IIIa (integrin a_llbb3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factors J Biol Chem 1992; 267: 11300-11306
• 29 Van Zanten GH, De Graaf S, Slootweg PJ, Heijnen HF G, Connolly TM, de Groot PG, Sixma JJ. Increased platelet deposition on atherosclerotic coronary arteries. J Clin Invest 1994; 93: 615-632
• 30 O’Brien ER, Garvin MR, Stweart DK, Hinohara T, Simpson JB, Schwartz SM, Giachelli CM. Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restentotic human coronary atherosclerotic plaques. Aiterioscler Thromb 1994; 14: 1648-1656
• 31 Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol 1994; 6: 695-704
• 32 Gawaz MP, Loftus JC, Bajt ML, Frojmovic MM, Plow EF, Ginsberg MH. Ligand bridging mediates integrin a_llbb₃ (platelet GPIIB-IIIA) dependent homotypic and heterotypic cell-cell interactionss. J Clin Invest 1991; 88: 1128-1134
• 33 Fox JE B. The platelet cytoskeleton. Thromb Haemost 1993; 70: 884-893
• 34 Cohen I, Burk DL, White JG. The effect of peptides and monoclonal antibodies that bind to platelet glycoprotein Ilb-IIIa complex on the development of clot tension. Blood 1989; 73: 1880-1887
• 35 The Epic Investigators. Use of a monoclonal antibody directed against the platelet glycoprotein Ilb/IIIa receptor in high-risk coronary angioplasty New Engl J Med 1994; 330: 956-961
• 36 Murphy JF, Bordet J-C, Wyler B, Rissoan M-C, Chomarat P, Defrance T, Miossec P, McGregor JL. The vitronectin receptor (α_vβ₃) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells. Biochem J 1994; 304: 537-542
• 37 Brooks PC, dark RA F, Cheresh DA. Requirement of vascular integrin α_vβ₃ for angiogenesis. Science 1994; 264: 569-571
• 38 Cheresh DA, Berliner SA, Vicente V, Ruggeri ZM. Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cell 1989; 58: 945-953
• 39 Diazflores L, Gutierrez R, Varela H. Angiogenesis-An update. Histol Histopathol 1994; 9: 807-843
• 40 Enenstein J, Kramer RH. Confocal microscopic analysis of integrin expression on the microvasculature and its sprouts in the neonatal foreskin. J Invest Dermatol 1994; 103: 381-386
• 41 Gamble JR, Matthias LJ, Meyer G, Kaur P, Russ G, Faull R, Bemdt MC, Vadas MA. Regulation of in vitro capillary tube formation by anti-integrin antibodies. J Cell Biol 1993; 121: 931-943
• 42 Davis CM, Danehower SC, Laurenza A, Molony JL. Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation. J Cell Biochem 1993; 51: 206-218
• 43 Brooks PC, Montgomery AM P, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA. Integrin α_vβ₃ antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994; 79: 1157-1164
• 44 Meredith J, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Molec Biol Cell 1993; 4: 953-961
• 45 Re F, Zanetti A, Sironi M, Polentarutti N, Lanfrancone L, Dejana E, Colotta F. Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol 1994; 127: 537-546
• 46 Montgomery AM P, Reisfeld RA, Cheresh DA. Integrin α_vβ₃ rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci USA 1994; 91: 8856-8860
• 47 Basson CT, Kocher O, Basson MD, Asis A, Madri JA. Differential modulation of vascular cell integrin and extracellularmatrix expression in vitro by TGF- beta-1 correlates with reciprocal effects on cell migration. J Cell Biochem 1992; 153: 118-128
• 48 Clyman RI, Tannenbaum J, Chen YQ, Cooper D, Yurchenko PD, Kramer RH, Waleh NS. Ductus arteriosus smooth muscle cell migration on collagen-Dependence on laminin and its receptors. J Cell Sci 1994; 107: 1007-1018
• 49 Matsuno H, Stassen JM, Vermylen J, Deckmyn H. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation. Circ 1994; 90: 2203-2203
• 50 Ginsberg MH, Du X, Plow EF. Inside-out integrin signalling. Curr Opin Cell Biol 1992; 4: 766-771
• 51 Huang M-M, Lipfert L, Cunningham M, Bmgge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin α_lllbβ₃ stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp 125^FAK . J Cell Biol 1993; 122: 473-483
• 52 Clark EA, Brugge JS. Redistribution of activated pp60^c-trc to integrin-dependent cytoskeletal complexes in thrombin -stimulated platelets. Mol Cell Biol 1993; 13: 1863-1871
• 53 Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem 1993; 268: 15868-15877
• 54 Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase, pp72^ryk, by platelet agonists and the integrin,α_llbβ₃ . J Biol Chem 1994; 46: 28859-28864
• 55 Lipfert L, Haimovich B, Schaffer MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase ppl25^FAK in platelets. J Cell Biol 1992; 119: 905-912
• 56 Fox JE B, Lipfert L, Clark EA, Reynolds CC, Austin CD, Brugge JS. On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP Ilb-IIIa, pp60^c-trc, pp60^c-yes, and the p21^ras GTPase-activating protein with the membrane skeleton. J Biol Chem 1993; 268: 25973-25984
• 57 Sims PJ, Ginsberg MH, Plow EF, Shattil SJ. Effect of platelet activation on the conformation of the plasma membrane glycoprotein Ilb-IIIa complex. J Biol Chem 1991; 266: 7345-7352
• 58 Abrams C, Deng J, Steiner B, Shattil SJ. Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin α_llbβ₃ . J Biol Chem 1994; 269: 18781-18788
• 59 Fox J, Shattil SJ, Kinlough-Rathbone R, Richardson M, Packham MA, Sanan DA. Regulation of transmembrane signaling by integrin α_llbβ₃-cytoskeleton interactions. J Biol Chem. 1995 (in press)
• 60 Chen Y-P, Djaffar I, Pidard D, Steiner B, Cieutat A-M, Caen JP, Rosa J-P. Ser-752 -> Pro mutation in the cytoplasmic domain of integrin β₃ subunit and defective activation of platelet integrin α_vβ₃ (glycoprotein Ilb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 1992; 89: 10169-10173
• 61 Wang R, Ambruso DR, Newman PJ. Truncation in the cytoplasmic domain of integrin β₃ subunit confers an inactivated state to the α_llbβ₃ complex in a variant type of Glanzmann thrombasthenia. Blood 1994; 84: 244-244 a
• 62 O’Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994; 124: 1047-1059
• 63 Chen Y-P, O’Toole TE, Shipley T, Forsyth J, La Flamme SE, Yamada KM, Shattil SJ, Ginsberg MH. “Inside-out” signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem 1994; 269: 18307-18310
• 64 Ridley AJ, Hall A. The small GTP-binding proten rho regulates the assembly of focal adhesions and actin stress fibres in response to growth factors. Cell 1992; 70: 389-399
• 65 Chrzanowska-Wodnicka M, Burridge K. Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. J Cell Sci 1994; 107: 3643-3654
• 66 Moolenaar WH. LPA: a novel lipid mediator with diverse biological actions. Trends Cell Biol 1994; 4: 213-218
• 67 Hall A. Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu Rev Cell Biol 1994; 10: 31-54
• 68 Lamarche N, Hall A. GAPS for rho-related GTPases. Trends Genet 1994; 10: 436-440
• 69 Narumiya S, Morii N. rho gene products, botulinum C3 exoenzyme and cell adhesion. Cell Signal 1993; 5: 9-19
• 70 Barry ST, Critchley DR. The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both ppl25^FAK and protein kinase C-δ to focal adhesions. J Cell Sci 1994; 107: 2033-2045
• 71 Ridley AJ, Hall A. Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J 1994; 13: 2600-2610
• 72 Chong LD, Traynor-Kaplan A, Bokoch GM, Schwartz MA. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell 1994; 79: 507-513
• 73 Nemoto Y, Namba T, Tera-uchi T, Ushikubi F, Morii N, Narumiya S. A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein J Biol Chem 1992; 267: 20916-20920
• 74 Eichholtz T, Jalink K, Fahrenfort I, Moolenaar WH. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biodiem J 1993; 291: 677-680
• 75 Morii N, Tem-uchi T, Tominaga T, Kumagai N, Kozaki S, Ushikubi F, Naramiya S. A rho gene product in human blood platelets II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platelet aggregation J Biol Chem 1992; 267: 20921-20926
• 76 Romer LH, Burridge K, Turner CE. Signaling between the extracellular matrix and the cytoskeleton: Tyrosine phosphoiylation and focal adhesion assembly. Cold Spring Haibor Symp Quant Biol 1992; 57: 193-202
• 77 Clark EA, Shattil SJ, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 1994; 19: 464-469
• 78 Bachelot C, Cano E, Grelac F, Saleun S, Draker BJ, Levy-Toledano S, Fischer S, Rendu F. Functional implications of tyrosine protein phosphorylation in platelets. Simultaneous studies with different agonists and inhibitors. Biochem J 1992; 284: 923-928
• 79 Kapeller R, Cantley LC. Phosphatidylinositol 3-kinase. BioEssays 1994; 16: 565-576
• 80 Zhang J, Fiy MJ, Waterfield MD, Jaken S, Liao L, Fox JE B, Rittenhouse SE. Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets. J Biol Chem 1992; 267: 4686-4692
• 81 Kovacsovics TJ, Bachelot C, Toker A, Vlahos C, Duckworth B, Cantley LC, Hartwig JH. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets, but reverses platelet aggregation. J Biol Chem. 1995 (in press)
• 82 Eigenthaler M, Walter U. Signal transduction and cyclic nucleotides in human platelets. Thromb Haemorrh Disorders 1994; 8: 41-46
• 83 Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125^FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem 1994; 269: 14738-14745
• 84 Cobb BS, Schaller MD, Leu T-H, Parsons JT. Stable association of pp60^srcand pp59^fyn with the focal adhesion-associated protein tyrosine kinase, pp125^FAK . Mol Cell Biol 1994; 14: 147-155
• 85 Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 1995; 15: 954-963
• 86 Schaller MD, Parsons JT. Focal adhesion kinase and associated proteins. CurrOpin Cell Biol 1994; 6: 705-710
• 87 Chen Q, Kinch MS, Lin TH, Burridge K, Juliano RL. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J Biol Chem 1994; 269: 26602-26605
• 88 Sastiy SK, Horwitz AF. Integrin cytoplasmic domains: Mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. CurrOpin Cell Biol 1993; 5: 819-831
• 89 Pavalko FM, Otey CA. Role of adhesion molecule cytoplasmic domains in mediating interactions with the cytoskeleton. Proc Soc Exp Biol Med 1994; 205: 282-293
• 90 Chen H-C, Guan J-L. Stimulation of phosphatidylinositol 3’-kinase association with focal adhesion kinase by platelet-derived growth factor. J Biol Chem 1994; 269: 31229-31233
• 91 Leung-Hagesteijn CY, Milankov K, Michalak M, Wilkins J, Dedhar S. Cell attachment to extracellular matrix substrates is inhibited upon downregulation of expression of calreticulin, an intracellular integrin a-subunit-binding protein. J Cell Sci 1994; 107: 589-600
• 92 Vuori K, Ruoslahti E. Association of insulin receptor substrate-1 with integrins. Science 1994; 266: 1576-1578
• 93 Schlaepfer DD, Hanks SK, Hunter T, Van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 1994; 372: 786-791
• 94 Schwartz MA. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. J Cell Biol 1993; 120: 1003-1010
• 95 Leavesley DI, Schwartz MA, Rosenfeld M, Cheresh DA. Integrin β1 - and β3-mediated endothelial cellmigration is triggered through distinct signaling mechanisms. J Cell Biol 1993; 121: 163-170
• 96 Defilippi P, Bozzo C, Volpe G, Romano G, Venturino M, Silengo L, Tarone G. Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphroylation events. Cell Adhesion Commun 1994; 2: 75-86
• 97 Romer LH, McLean N, Turner CE, Burridge K. Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells. Molec Biol Cell 1994; 5: 349-361
• 98 Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis M. Agonist receptors and G proteins as mediators of platelet activation. Adv Exp Med Biol 1993; 344: 17-36