DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 07 · Volume 74 · 1995 DOI: 10.1055/s-009-45162

Special Colloquium

  • 001
    Davie, Earl W:

    Biochemical and Molecular Aspects of the Coagulation Cascade

  • 007
    Rapaport, Samuel I; Rao, L Vijaya Mohan:

    The Tissue Factor Pathway: How It Has Become a “Prima Ballerina”

  • 018
    Caen, Jacques P; Rosa, Jean-Philippe:

    Platelet-Vessel Wall Interaction: from the Bedside to Molecules

  • 025
    Verstraete, Marc:

    The Fibrinolytic System: from Petri Dishes to Genetic Engineering

    • Colloquium

    The Haemophilias-An Update

  • 036
    Evatt, Bruce L:

    AIDS and Hemophilia - Current Issues

  • 040
    Peake, Ian:

    Molecular Genetics and Counselling in Haemophilia

  • 045
    Thompson, Arthur R:

    Progress Towards Gene Therapy for the Hemophilias

    • Symposium

    Vascular Wall Cells

  • 052
    Rosenberg, Robert D:

    The Absence of the Blood Clotting Regulator Thrombomodulin Causes Embryonic Lethality in Mice Before Development of a Functional Cardiovascular System

  • 058
    Pinsky, David J:

    The Vascular Biology of Heart and Lung Preservation for Transplantation

    • Natural Inhibitors of Fibrinolysis

  • 066
    Deng, Gang; Royle, Gordon; Seiffert, Dietmar; Loskutoff, David J:

    The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

    • Special Colloquium

    Natural Inhibitors Of fibrinolysis

  • 071
    Wiman, Björn:

    Plasminogen Activator Inhibitor 1 (PAI-1) in Plasma: Its Role in Thrombotic Disease

    • Symposium

    Platelets,Prostaglandins,Lipids,NO

  • 077
    Szczeklik, Andrzej:

    Thrombin Generation in Myocardial Infarction and Hypercholesterolemia: Effects of Aspirin

    • Colloquium

    Natural Inhibitors of Blood Coagulation

  • 081
    Aiach, Martine; Gandrille, Sophie; Emmerich, Joseph:

    A Review of Mutations Causing Deficiencies of Antithrombin, Protein C and Protein S

    • Natural Inhibitors of Blood Cogulation

  • 090
    Broze, George J:

    Tissue Factor Pathway Inhibitor

  • 094
    Bauer, Kenneth A:

    Management of Patients with Hereditary Defects Predisposing to Thrombosis Including Pregnant Women

    • Symposium

    Thrombolytic Thearpy

  • 101
    Marder, Victor J:

    Thrombolytic Therapy: Overview of Results in Major Vascular Occlusions

    • Thrombolytic Therapy

  • 106
    Samama, M M; Acar, J:

    Thrombolytic Therapy: Future Issues

    • Platelet Activation and Signal Transduction

  • 111
    Clemetson, Kenneth J:

    Platelet Activation: Signal Transduction Via Membrane Receptors

    • Hemorheology

  • 117
    Weiss, Harvey J:

    Flow-Related Platelet Deposition on Subendothelium

  • 123
    Grabowski, Eric F; Lam, Frances P:

    Endothelial Cell Function, Including Tissue Factor Expression, Under Flow Conditions

    • Thrombin - Bilogical Activities

  • 129
    Guillin, Marie-Claude; Bezeaud, Annie; Bouton, Marie-Christine; Jandrot-Perrus, Martine:

    Thrombin Specificity

  • 134
    Hemker, H Coenraad; Béguin, Suzette:

    Thrombin Generation in Plasma: Its Assessment Via the Endogenous Thrombin Potential

    • Plenary Lecture

  • 139
    Dahlbäck, Björn:

    New Molecular Insights into the Genetics of Thrombophilia. Resistance to Activated Protein C Caused by Arg506 to Gin Mutation in Factor V as a Pathogenic Risk Factor for Venous Thrombosis

  • 149
    Shattil, Sanford J:

    Function and Regulation of the β3 Integrins in Hemostasis and Vascular Biology

  • 302
    Coller, Barry S; Anderson, Keaven; Weisman, Harlan F:

    New Antiplatelet Agents: Platelet GPIIb/llla Antagonists

  • 309
    Dejana, Elisbetta; Maschio, Aldo Del:

    Molecular Organization and Functional Regulation of Cell to Cell Junctions in the Endothelium

    • Symposium

    Von Willebrand Disease and Factor

  • 156
    Girma, Jean-Pierre; Ribba, Anne-Sophie; Meyer, Dominique:

    Structure-Function Relationship of the A1 Domain of von Willebrand Factor

  • 161
    Sadler, J Evan; Matsushita, Tadashi; Dong, Zhengyu; Tuley, Elodee A; Westfield, Lisa A:

    Molecular Mechanism and Classification of von Willebrand Disease

    • Molecular Basis of Fibrinolysis

  • 167
    Collen, D; Lijnen, H R:

    Molecular Basis of Fibrinolysis, as Relevant for Thrombolytic Therapy

  • 172
    Bachmann, F:

    The Enigma PAI-2. Gene Expression, Evolutionary and Functional Aspects

    • Tissue Factor

  • 180
    Nemerson, Yale:

    Tissue Factor: Then and Now

  • 185
    Morrissey, James H:

    Tissue Factor Modulation of Factor Vlla Activity:Use in Measuring Trace Levels of Factor Vlla in Plasma

    • Venous Thromboembolism:Diagnosis and Therapy

  • 189
    Hull, Russell D; Feldstein, William; Pineo, Graham F; Raskob, Gary E:

    Cost Effectiveness of Diagnosis of Deep Vein Thrombosis in Symptomatic Patients

  • 197
    ten Cate, Jan W; Koopman, Maria M W; Prins, Martin H; Büller, Harry R:

    Treatment of Venous Thromboembolism

    • Megakaryocytes

  • 204
    Gewirtz, Alan M:

    Megakaryocytopoiesis: The State of the Art

  • 210
    Uzan, Georges; Prandini, Marie Hélè; Berthier, Rolande:

    Regulation of Gene Transcription During the Differentiation of Megakaryocytes

    • Colloquium

    Platelets,Leukocytes and Endothelial Cells During Inflammation and Thrombosis

  • 213
    Marcus, Aaron J; Safier, Lenore B; Broekman, M Johan; Islam, Naziba; Fliessbach, Joan H; Hajjar, Katherine A; Kaminski, Wolfgang E; Jendraschak, Ellen; Silverstein, Roy L; von Schacky, Clemens:

    Thrombosis and Inflammation as Multicellular Processes: Significance of Cell-Cell Interactions

  • 218
    Cerletti, Chiara; Evangelista, Virgilio; Molino, Marina; de Gaetano, Giovanni:

    Platelet Activation by Polymorphonuclear Leukocytes: Role of Cathepsin G and P-Selectin

  • 224
    Furie, Bruce; Furie, Barbara C:

    The Molecular Basis of Platelet and Endothelial Cell Interaction with Neutrophils and Monocytes: Role of P-Selectin and the P-Selectin Ligand, PSGL-1

    • Disorders Causing Thrombocytopenia

  • 228
    Kelton, John G:

    The Serological Investigation of Patients with Autoimmune Thrombocytopenia

  • 234
    Newman, Peter J; Valentin, Nathalie:

    Human Platelet Alloantigens: Recent Findings, New Perspectives

  • 240
    Moake, Joel L:

    Thrombotic Thrombocytopenic Purpura

  • 246
    Machin, S J; Kelsey, H; Seghatchian, M J; Warwick, R; Mackie, I J:

    Platelet Transfusion

    • Symposium

    Adhesive Proteins,Integrins,Selectins

  • 253
    Ugarova, Tatiana; Agbanyo, Francisca R; Plow, Edward F:

    Conformational Changes in Adhesive Proteins Modulate Their Adhesive Function

  • 258
    Hess, Sibylle; Kanse, Sandip M; Kost, Christine; Preissner, Klaus T:

    The Versatility of Adhesion Receptor Ligands in Haemostasis: Morpho-Regulatory Functions of Vitronectin

    • Gene Therapy of Haemophilia A and B

  • 266
    Fallaux, Frits J; Hoeben, Rob C; Briët, Ernest:

    State and Prospects of Gene Therapy for the Hemophilias

  • 274
    Furie, Barbara C; Furie, Bruce:

    Biosynthesis of Factor IX: Implications for Gene Therapy

    • Thrombosis Cancer

  • 278
    Donati, Maria Benedetta:

    Cancer and Thrombosis: from Phlegmasia Alba Dolens to Transgenic Mice

  • 282
    Nierodzik, Mary Lynn; Klepfish, Abraham; Karpatkin, Simon:

    Role of Platelets, Thrombin, Integrin llb-llla, Fibronectin and Von Willebrand Factor on Tumor Adhesion in Vitro and Metastasis in Vivo

    • Regulation of Fibrinolysis by Cells and ECM

  • 291
    Loscalzo, Joseph; Pasche, Boris; Quimet, Helene; Freedman, Jane E:

    Platelets and Plasminogen Activation

  • 294
    Hajjar, Katherine A:

    Cellular Receptors in the Regulation of Plasmin Generation

    • Molecular Basis of Haemophilias

  • 313
    Tuddenham, Edward G D; Pemberton, Susan; Cooper, David N:

    Inherited Factor VII Deficiency: Genetics and Molecular Pathology

  • 322
    Antonarakis, Stylianos E:

    Molecular Genetics of Coagulation Factor VIII Gene and Hemophilia A

    • Antiphospholipid Antibodies

  • 329
    Triplett, Douglas A:

    Protean Clinical Presentation of Antiphospholipid-Protein Antibodies (APA)

  • 338
    Exner, Thomas:

    Diagnostic Methodologies for Circulating Anticoagulants

    • Platler Glycoproteins and Genetic Disorders

  • 345
    Nurden, Alan T:

    Polymorphisms of Human Platelet Membrane Glycoproteins: Structure and Clinical Significance

  • 352
    Ginsberg, Mark H; Du, Xiaoping; O'Toole, Timothy E; Loftus, Joseph C:

    Platelet lntegrins

    • Low Molecular Weight Heparin

  • 360
    Hirsh, Jack; Siragusa, Sergio; Cosmi, Benilda; Ginsberg, Jeffrey S:

    Low Molecular Weight Heparins (LMWH) in the Treatment of Patients with Acute Venous Thromboembolism

  • 364
    Kakkar, V V:

    Effectiveness and Safety of Low Molecular Weight Heparins (LMWH) in the Prevention of Venous Thromboembolism (VTE)

    • Platelet Vessel Wall Interaction as a Target of Antithrombotic Therapy

  • 369
    Hawiger, Jacek:

    Mechanisms Involved in Platelet Vessel Wall Interaction

    • Platelet Vessel Wall Interaction as a Target of Antithrombotic Terapy

  • 373
    Leung, Lawrence L.K:

    Application of Combinatorial Libraries and Protein Engineering to the Discovery of Novel Anti-Thrombotic Drugs

  • 377
    Vermylen, J:

    Clinical Trials of Primary and Secondary Prevention of Thrombosis and Restenosis

    • Thrombi as a Target of Therapy

  • 382
    Harpel, Peter C; Hermann, Anita; Zhang, Xiaoxia; Ostfeld, Iris; Borth, Wolfgang:

    Lipoprotein(a), Plasmin Modulation, and Atherogenesis

  • 387
    Lijnen, H R; Collen, D:

    Fibrinolytic Agents: Mechanisms of Activity and Pharmacology

    • Leukocytes, Thrombosis and Haemostasis

  • 391
    Rickels, Federick R; Hair, Gregory A; Zelf, Richard A; Lee, Elsbeth; Bona, Robert D:

    Tissue Factor Expression in Human Leukocytes and Tumor Cells

    • Antiplatelet Drugs

  • 396
    Patrono, Carlo; Patrignani, Paola; Rocca, Bianca; Landolfi, Raffele:

    Characterization of Biochemical and Functional Effects of Antiplatelet Drugs as a Key to Their Clinical Development

  • 401
    Goodnight, Scott H:

    Antiplatelet Therapy with Aspirin: From Clinical Trials to Practice

    • Vaascular Growth Factor

  • 406
    Flugelman, Moshe Y:

    Inhibition of Intravascular Thrombosis and Vascular Smooth Muscle Cell Proliferation by Gene Therapy

  • 411
    Maciag, T; Friesel, R E:

    Molecular Mechanisms of Fibroblast Growth Factor-1 Traffick, Signaling and Release

    • Perinatal Haemostasis

  • 415
    Andrew, Maureen:

    Developmental Hemostasis: Relevance to Thromboembolic Complications in Pediatric Patients

  • 426
    Bussel, James B:

    Fetal Neonatal Thrombocytopenia

    • Plenary Lecture

  • 429
    Carmeliet, Peter; Collen, Désiré:

    Gene Targeting and Gene Transfer Studies of the Biological Role of the Plasminogen/Plasmin System

  • 565
    Turpie, Alexander G G; Weitz, Jeffrey I; Hirsh, Jack:

    Advances in Antithrombotic Therapy: Novel Agents

    • Management of Haemophilias

  • 437
    Mannucci, Pier Mannuccio:

    Effects of Factor VIII Concentrates on the Immune System of Patients with Hemophilia

  • 440
    Aledort, Louis M:

    Some Aspects on the Management of Hemophilia

    • Activated Protein C Resistance

  • 444
    Griffin, John H; Heeb, Mary J; Kojima, Yumi; Fernández, José A; Kojima, Kazuhisa; Hackeng, Tilman M; Greengard, Judith S:

    Activated Protein C Resistance: Molecular Mechanisms

  • 449
    Bertina, Rogier M; Reitsma, Pieter H; Rosendaal, Frits R; Vandenbroucke, Jan P:

    Resistance to Activated Protein C and Factor V Leiden as Risk Factors for Venous Thrombosis

    • Platelet Vessel Wall and Fibrinogen Interactions

  • 454
    Sixma, Jan J; Van Zanten, G Henrita; Saelman, Edwin U M; Verkleji, Marilyn; Lankhof, Hanneke; Nieuwenhuis, H Karel; Groot, Philip G de:

    Platelet Adhesion to Collagen

  • 460
    Ruggeri, Zaverio M:

    The Role of von Willebrand Factor and Fibrinogen in the Initiation of Platelet Adhesion to Thrombogenic Surfaces

    • New Antithrombins

  • 464
    Harker, Laurence A; Hanson, Stephen R; Kelly, Andrew B:

    Antithrombotic Benefits and Hemorrhagic Risks of Direct Thrombin Antagonists

  • 473
    Callas, Demetra; Fareed, Jawad:

    Comparative Pharmacology of Site Directed Antithrombin Agents. Implication in Drug Development

    • Clinical Users of Fibric Sealant

  • 482
    Spotnitz, William D:

    Fibrin Sealant in the United States: Clinical Use at the University of Virginia

    • Clinical Uses of Fibrin Sealant

  • 486
    Martinowitz, Uri; Schulman, Sam:

    Fibrin Sealant in Surgery of Patients with a Hemorrhagic Diathesis

    • Thrombin as a Target of Antithrombotic Therapy

  • 493
    Fenton II, John W:

    Thrombin Functions and Antithrombotic Intervention

  • 499
    Brass, Lawrence F:

    Issues in the Development of Thrombin Receptor Antagonists

    • Clinical Coagulation Laboratory and Oral Anticoagulant Therapy Treatment

  • 506
    Altman, Raul; Rouvier, Jorge; Gurfinkel, Enrique:

    Oral Anticoagulant Treatment with and without Aspirin

  • 511
    Barbui, Tizsano; Finazzi, Guido; Remuzzi, Andrea:

    Clinical Coagulation Laboratory and Oral Anticoagulant Therapy Treatment. Instrumentation and Methodology

    • Clinical Coagulation Laboratory and Oral Anticoagulation Therapy Treatment

  • 515
    Preston, F E:

    Quality Control and Oral Anticoagulation

    • Thrombopoietin

  • 521
    Kaushansky, Kenneth:

    Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet Production

  • 526
    Vainchenker, William; Methia, Nassia; Debili, Najet; Titeux, Monique; Wendling, Françoise:

    c-mpl, the Thrombopoietin Receptor

    • Extracellular Matrix

  • 529
    Mosher, Deane F:

    Organization of the Provisional Fibronectin Matrix: Control by Products of Blood Coagulation

  • 534
    Vlodavsky, Israel; Miao, Hua-Quan; Atzmon, Ruth; Levi, Ehud; Zimmermann, Joseph; Bar-Shavit, Rachel; Peretz, Tamar; Ben-Sasson, Shmuel A:

    Control of Cell Proliferation by Heparan Sulfate and Heparin-Binding Growth Factors

    • Restenosis

  • 541
    Schwartz, Stephen M; Reidy, Michael A; O’Brien, Edward R M:

    Assessment of Factors Important in Atherosclerotic Occlusion and Restenosis

  • 552
    Fuster, Valentin; Falk, Erling; Fallon, John T; Badimon, Lina; Chesebro, James H; Badimon, Juan Jose:

    The Three Processes Leading to Post PTCA Restenosis: Dependence on the Lesion Substrate

    • Liproproteins and Thrombosis

  • 560
    Aviram, Michael:

    LDL-Platelet Interaction Under Oxidative Stress Induces Macrophage Foam Cell Formation