Thromb Haemost 1995; 74(01): 552-559
DOI: 10.1055/s-0038-1642737
Symposium
Restenosis
Schattauer GmbH Stuttgart

The Three Processes Leading to Post PTCA Restenosis: Dependence on the Lesion Substrate

Valentin Fuster
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
,
Erling Falk
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
,
John T Fallon
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
,
Lina Badimon
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
,
James H Chesebro
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
,
Juan Jose Badimon
Cardiovascular Biology Research Laboratory, Cardiovascular Institute Mount Sinai School of Medicine, New York, NY, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
09 July 2018 (online)

 
  • References

  • 1 Fuster V. Lewis A Conner Memorial Lecture. Mechanisms leading to myocardial infarction: Insights from studies of vascular biology Circulation 1994; 4: 2126-2146
  • 2 Ip J, Fuster V, Israel D, Badimon L, Badimon JJ, Stein B, Chesebro J. The roleä of platelets, thrombin and hyperplasia in restenosis after coronary angioplasty. J Am Coll Cardiol 1991; 17: 77B-88
  • 3 Hjemdhal-Monsen CE, Ambrose J A, Borneo S. et al. Angiographic patterns of balloon inflation during PTCA. Role of pressure-diameter curves in studying distensibility and elasticity of the stenotic lesion and the mechanism of dilation JACC 1990; 16: 569-575
  • 4 Hanet C, Wijns W, Michel X, Schroeder E. Influence of balloon size and stenosis morphology on immediate and delayed elastic recoil after PTCA. J Am Coll Cardiol 1991; 18: 506-511
  • 5 Strikwerda S, Montauban E, Melkert R, Serruys PW. Quantitative angiographic comparison of elastic recoil after coronary excimer laser-assisted balloon angioplasty and balloon angioplasty alone. J Am Coll Cardiol 1995; 25: 378-386
  • 6 Rodriguez A, Santaera O, Larribeau M, Sosa M, Palacios I. Early decrease in minimal lumen diameter after successful PTCA predicts late restenosis. Ami Cardiol 1993; 71: 1391-1395
  • 7 Kuntz RE, Gibson M, Nobuyoshi M, Bairn D. Generalized model of restenosis after conventional balloon angioplasty, stenting And directional atherectomy. J Am Coll Cardiol 1993; 21: 5-25
  • 8 Umans V, Keane D, Foley D, Boersma E, Melkert R, Serruys P. Optimal Use of directional coronary atherectomy is required to ensure long-term angiographic benefit: A study with matched procedural outcome after atherectomy and angioplasty. J Am Coll Cardiol 1994; 24: 1652-1659
  • 9 Serruys PW, de Jaegere P, Kliemeneij F, Macaya C. et al. A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent Study Group N Engl J Med 1994; 331: 489-495
  • 10 Fischman DL, Leon MB, Bairn DS. et al. A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease. N Engl J Med 1994; 331: 496-501
  • 11 Femandez-Ortiz A, Badimon JJ, Falk E, Fuster V, Meyer B, Mailhac A, Weng D, Shah PK, Badimon L. Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture. J Am Coll Cardiol 1994; 23: 1562-1569
  • 12 Meyer B, Fernandez Ortiz A, Mailhac A, Falk E, Badimon L, DonMichael T, Chesebro J, Fuster V, Badimon JJ. Local delivery of hirudin by a double balloon perfusion catheter prevents mural thrombosis and minimizes platelet deposition after angioplasty. Circulation 1994; 90: 2474-2480
  • 13 Badimon L, Badimon JJ. Mechanism of arterial thrombosis in non-parallel streamlines: platelet-thrombi grow on the apex of stenotic severely injured vessel wall. J din Invest 1989; 84: 1134-1144
  • 14 Mailhac A, Badimon JJ, Fallon JT, Femandez-Ortiz Meyer B, uster V, Badimon L. Effect of an eccentric severe stenosis on fibrin(ogen) deposition xi severely damaged vessel wall in arterial thrombosis. Relative contribution of platelets and fibrin(ogen) Circulation 1994; 90: 988-996
  • 15 Moreno P, Falk E, Palacios I, Newell JB, Fuster V, Fallon JT. Macrophage infiltration in acute coronary syndromes. Implications for plaque rapture Circulation 1994; 90: 775-778
  • 16 Topol EJ, Califf RM, Weisman HF. et al. Randomised trial of coronary intervention with antibody against platelet Ilb/IIIa integrin for reduction of clinical restenosis: Results at six months. The EPIC investigators Lancet 1994; 343: 881-886
  • 17 The EPIC Investigators. Use of monoclonal antibody directed against the platelet glycoprotein Ilb/IIIa receptor in high-risk coronary angioplasty. N Engl J Med 1994; 14: 956-961
  • 18 van den Bos A, Deckers J, Heyndricks G. et al. Safety and efficacy of recombinant hirudin vs heparin in patients with stable angina undergoing coronary angioplasty. Circulation 1993; 88: 2058-2066
  • 19 Lindner V, Reidy MA. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against bFGF. Proc Natl Acad Sci USA 1991; 88: 3739-3743
  • 20 Lindner V, Reidy MA. Expression of bFGF and its receptor by smooth muscle cells and endothelium in injured rat arteries. Circ Res 1993; 73: 589-595
  • 21 Nabel EG, Yang Z. Plautz et al. rFGF-1 gene expression in porcine arteries induces intimal hyperplasia and angiogenesis in vivo. Nature 1993; 362: 844-846
  • 22 Nabel EG, Liptay S. Yang et al. r-PDGF gene expression in porcine arteries induces intimal hyperplasia in vivo. J Clin Invest 1993; 91: 1822-1829
  • 23 Nabel EG, Shum L, Pompili VJ. et al. Direct gene transfer of TGF-bl in the arterial wall stimulates fibrocellular hyperplasia. Proc Natl Acad Sci USA 1993; 90: 10759-10764
  • 24 Thyberg J, Heldin U, Sjolund M, Palmberg L, Bottger BA. Regulation of differentiated properties and proliferation of arterial SMC. Arteriosclerosis 1990; 10: 966-990
  • 25 McNamara CA, Sarembock I, Gimple L, Fenton J, Couglhin SR, Owens GK. Thrombin stimulates proliferation of cultured rat aortic SMC by a proteolitically activated receptor. J Clin Invest 1993; 91: 94-98
  • 26 Bar-Shavit R, Benezra M, Eldor A, Hy-Am E, Fenton JW, Wilner GD. Thrombin immobilized to extracellular matrix is a potent mitogen for vascular SMC: Nonenzymatic model of action. Cell Regulation 1990; 1: 453-463
  • 27 Nelken NA, Soiler J, O’Keefe J, Vu TK, Charo I, Coughlin S. Thrombin receptor expression in normal and atherosclerotic human arteries. J Clin Invest 1992; 90: 1614-1622
  • 28 Noda H, Fuji S, Sobel B. Induction of vascular SMC expression of PAI-1 by thrombin. Circ Res 1993; 72: 36-43
  • 29 Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D. PDGF mRNA detection in human atherosclerotic human plaques by in situ hybridization. J Clin Invest 1988; 82: 1134-1143
  • 30 Ross R, Masuda J, Raines EW, Gown AM, Matsuda S. et al. Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science 1988; 248: 1009-1012
  • 31 Sarembock IJ, Gertz SD, Gimple LW, Owen RM, Powers ER, Roberts WC. Effectiveness of recombinant desulphatohiradin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation 1991; 84: 232-243
  • 32 Seifert RA, Schwartz SM, Bowen-Pope DF. Developmentally regulated production of platelet-derived growth factor-like molecules. Nature 1984; 311: 669-671
  • 33 Kleihman HK, Martin GR. Platelet-derived growth factor is a chemoattractant factor for vascular smooth muscle cells. 1982; 113 (02) 267-266
  • 34 Ross R, Raines EW, Bowen-Pope DF. The biology of PDGF. Cell 1986; 46: 155-169
  • 35 Friedman RS, Stemerman MB, Wenz B, Moore S, Gavldie J, Gent M, Tiell ML, Spaet TH. The effect of thrombocytopenia an experimental atherosclerotic lesion formation in rabbits. SMC proliferation and re-endothelialization J Clin Invest 1977; 60: 1191
  • 36 Fingerle J, Johnson R, Clowes A, Majesky M, Reidy MA. Role of platelets in SMC proliferation and migration aftervascular injury in rat carotid artery. Proc Natl Acad Sci USA 1989; 86: 8412
  • 37 Willerson JT, Yao SK, McNatt J, Benedict CR, Anderson HV. et al. Frequency and severity of cyclic flow alterations and platelet aggregation predict the severity of neointimal proliferation following experimental coronaiy stenosis and endothelial injury. Proc Natl Acad Sci USA 1991; 88: 10624
  • 38 Willerson JT, Yao SK, McNatt J, Benedict C, Anderson H. et al. Frequency and severity of cyclic flow alterations and platelet aggregation predict the severity of neointimal proliferation following experimental coronary stenosis and endothelial injury. Proc Natl Acad Sci USA 1991; 88: 10624
  • 39 Badimon L, Rosemark J, Badimon J, Fuster V. High cholesterol diet induced atherosclerosis in homozygous and heterozygous von Willebrand pigs. Arteriosclerosis 1985; 5: 366-370
  • 40 Badimon L, Badimon JJ, Turitto VT, Vallabhajosula S, Fuster V. Platelet thrombus formation on collagen type I: A model of deep vessel injury. Influence of blood theology, von Willebrand factor and blood coagulation Circulation 1988; 78: 1431-1442
  • 41 Fuster V, Lie J, Badimon L, Rosemark J, Badimon JJ, Bowie EJ W. Spontaneous and diet induced coronary atherosclerosis in normal swine and swine with von Willebrand’s disease. Arteriosclerosis 1985; 5: 67-73
  • 42 Jawian A, Bowen-Pipe DF, Lindnes V, Schwartz SM, Clowes AM. Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty. J Clin Invest 1992; 89: 507
  • 43 Ferns G, Raines E, Spragel K, Motari A, Reidy M, Ross R. Inhibition of neointimal SMC accumulation after angioplasty by an antibody to PDGF. Science 1991; 253: 1129-1132
  • 44 Libby P, Schwartz D, Brogi E, Tanaka H, Clinton S. A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992; 86 Suppl (Suppl. 03) III 47-52
  • 45 Roberts AB, Spom MB. Physiological actions and clinical applications of TGF-B. Am J Physiol 1993; 264: 179-45186
  • 46 Gibbons G, Pratt R, Dzau V. Vascular SMC hypertrophy vs hyperplasia. Autocrine TGF-BB-1 expression determines growth response to angiotensin II J Clin Invest 1992; 90: 456-461
  • 47 Loskuttof DJ. Regulation of PAI-1 gene expression. Fibrinolysis 1991; 5: 197-206
  • 48 Farb A, Renu V, Atkinson JB, Andersen PG. Long-term histologic patency after percuitaneous transluminal coronary angioplasty is predicted by the creation of a greater lumen area. J Am Coll Cardiol 1994; 24: 1229-1235
  • 49 Jackson CL, Raines EW, Ross R, Reidy M. Role of endogenous PDGF in arterial SMC migration after balloon injury. Arteriosclerosis 1993; 13: 1129-1132
  • 50 Franklin SM, Faxon DP. Pharmacological prevention of restenosis after PTC A: review of randomized clinical trials. Coronaiy Ait Dis 1993; 232-242
  • 51 Maresta A, Balducelli M, Cantini L, Casari A, Chioin R, Fabbri M, Fontanelli A. äet al. Trapidil, a platelet-derived growth factor antagonist, reduces restenosis after percutaneous transluminal coronary angioplasty. Circulation 1994; 90: 2710-2715
  • 52 Fernandez Ortiz A, Meyer B, Mailhac A, Falk E, Badimon L, Fallon JT, Fuster V, Chesebro JH, Badimon JJ. A new approach forlocal intravascular drug delivery: Iontophoretic balloon. Circulation 1994; 89: 1518-1522
  • 53 Simmons M, Edelman E, DeKeyser J, Langer R, Rosenberg R. Antisense c-myboligonucleotides inhibit arterial smooth muscle cell in vivo. Nature 1992; 359: 67-70
  • 54 Conte MS, Birinyi LK, Miyate T, Fallon JT. et al. Efficient repopulation of denuded rabbit arteries with autologous genetically modified endothelial cells. Circulation 1994; 89: 2161-2169
  • 55 Ortu P, LaMuraglia GM, Roberts WG, Flotte TJ, Hassan T. Photodynamic therapy of arteries. A novel approach for treatment of experimental intimal hyperplasia Circulation 1992; 85: 1189-1193