A Prospective Study of Haemostatic Tests at 28 Weeks Gestation as Predictors of Pre-Eclampsia and Growth Retardation

J G Thornton; B J Molloy; P S Vinall; P R Philips; R Hughes; J A Davies

doi:10.1055/s-0038-1646567

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1989; 61(02): 243-245
DOI: 10.1055/s-0038-1646567

Original Article

Schattauer GmbH Stuttgart

A Prospective Study of Haemostatic Tests at 28 Weeks Gestation as Predictors of Pre-Eclampsia and Growth Retardation

Authors

J G Thornton

The Department of Obstetrics, Leeds General Infirmary, Leeds, UK
B J Molloy

The Department of Obstetrics, Leeds General Infirmary, Leeds, UK
P S Vinall

The Department of Obstetrics, Leeds General Infirmary, Leeds, UK
P R Philips

^**The Health Care Research Unit, University of Newcastle upon Tyne, UK
R Hughes

^*The Department of Gynaecology and Medicine, Leeds General Infirmary, Leeds, UK
J A Davies

^*The Department of Gynaecology and Medicine, Leeds General Infirmary, Leeds, UK

Abstract

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Summary

A panel of haemostatic tests was perfomed on 400 primiparous women at 28 weeks to test whether one or more could predict the development of pregnancy complications. Fifteen women subsequently developed pre-eclampsia with significant proteinuria and 13 delivered growth retarded infants. There were no significant differences between mothers in the pre-eclampsia group and 22 randomly selected controls. A stepwise logistic discriminant analysis of the data did not produce a significant model. In the growth retarded group only beta thromboglobulin levels were significantly lower than in the controls (p <0.05), although in the logistic discriminant analysis the inclusion of both beta thromboglobulin and fibrin degradation products led to a borderline significant improvement in fit of the model. We conclude that the haemostatic variables studied are not significantly changed at 28 weeks nor clinically useful predictors of either pre-eclampsia or fetal growth retardation.

Keywords

Haemostasis - Pre-eclampsia - Fetal growth retardation

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References

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