Defibrinogenation by Arvin Reduces Air-Drying-lnduced Arteriosclerosis in Rat Carotid Artery

E van Pelt-Verkuil; P van de Ree; J J Emeis

doi:10.1055/s-0038-1646568

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1989; 61(02): 246-249
DOI: 10.1055/s-0038-1646568

Original Article

Schattauer GmbH Stuttgart

Defibrinogenation by Arvin Reduces Air-Drying-lnduced Arteriosclerosis in Rat Carotid Artery

Authors

E van Pelt-Verkuil

The Gaubius Institute TNO, Leiden, The Netherlands
P van de Ree

The Gaubius Institute TNO, Leiden, The Netherlands
J J Emeis

The Gaubius Institute TNO, Leiden, The Netherlands

Abstract

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Summary

The effects of lowering plasma fibrinogen levels by Arvin injections have been investigated in a rat model of arteriosclerosis. In this model air-drying-induced endothelial denudation of the left carotid artery results in myointimal lesion development. Arvin (2 × 50 Units/kg) was given at 4 and 2 hours prior to surgery, reducing plasma fibrinogen levels at surgery to about 20%. Fibrinogen levels then normalized within 24 hours. Myointimal lesion development was evaluated morphometrically at 14 days after surgery. Statistical analysis of the morphometric data showed that defibrinogenation had resulted in significantly smaller myointimal lesions. Low plasma fibrinogen levels might thus be considered a negative risk factor for intimal smooth muscle cell proliferation in this model.

Keywords

Endothelial injury - Arterioscleros - Rat carotid artery - Rat carotid artery Defibrinogenation - Arvin - Morphometry

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References

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