Platelet Thromboxane A2/Endoperoxide (TXA2/PGH2)Receptors in Type I Diabetes mellitus

K Jaschonek; C Faul; C Weisenberger; K Krönert; H Schröder; W Renn

doi:10.1055/s-0038-1646631

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1989; 61(03): 535-536
DOI: 10.1055/s-0038-1646631

Letter to the Editor

Schattauer GmbH Stuttgart

Platelet Thromboxane A₂/Endoperoxide (TXA₂/PGH₂)Receptors in Type I Diabetes mellitus

K Jaschonek

Medizinische Klinik der Universität Tübingen, Otfried-Müller-Straße 10, D-7400 Tübingen, Federal Republic of Germany

,

C Faul

Medizinische Klinik der Universität Tübingen, Otfried-Müller-Straße 10, D-7400 Tübingen, Federal Republic of Germany

,

C Weisenberger

^*Dr. Karl Thomae GmbH, Abteilung Biochemie, D-7950 Biberach, Federal Republic of Germany

,

K Krönert

Medizinische Klinik der Universität Tübingen, Otfried-Müller-Straße 10, D-7400 Tübingen, Federal Republic of Germany

,

H Schröder

Medizinische Klinik der Universität Tübingen, Otfried-Müller-Straße 10, D-7400 Tübingen, Federal Republic of Germany

,

W Renn

Medizinische Klinik der Universität Tübingen, Otfried-Müller-Straße 10, D-7400 Tübingen, Federal Republic of Germany

› Author Affiliations

Abstract

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References

References
1 Banga JD, Sixma JJ. Diabetes mellitus, vascular disease and thrombosis. Clin Haematol 1986; 15: 465-492
2 Halushka PV, Rodgers RC, Loadholt CB, Colwell JA. Increased platelet thromboxane synthesis in diabetes mellitus. J Lab Clin Med 1981; 97: 87-96
3 Collier A, Tymkewycz P, Armstrong R, Young RJ, Jones RL, Clarke BF. Increased platelet thromboxane receptor sensitivity in diabetic patients with proliferative retinopathy. Diabetologia 1986; 29: 471-474
4 Gerrard JM, Stuart MJ, Rao GH R. et al Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats. J Lab Clin Med 1980; 95: 950-958
5 Morita I, Takahashi R, Ito H, Orimo H, Murota S. Increased arachidonic acid content in platelet phospholipids from diabetic patients. Prostaglandin Leukotrienes Med 1983; 11: 33-41
6 Brass LF, Shaller CC, Belmente E. Inositol 1,4,5-triphosphate-induced granule secretion in platelets. J Clin Invest 1987; 79: 1269-1275
7 Moffat KJ, MacIntyre DE. Regulation of receptor-operated Ca²⁺channel opening in human platelets. Thromb Haemostas 1987; 58: 509 (Abstr)
8 Funck M, Muller CP, Jaschonek K. Modulation of surface expression of human platelet prostacyclin receptors by cholesterol, dibucaine and pentoxifylline. Thrombos Res 1988; 52: 343-347
9 Alessandrini R, McRae J, Feman S, Fitzgerald GA. Thromboxane biosynthesis and platelet function in type I diabetes mellitus. N Engl J Med 1988; 319: 208-212
10 Jaschonek K, Faul C, Schmidt H, Renn W. Desensitization of platelets to iloprost. Loss of specific binding sites and heterologous desensitization of adenylate cyclase Eur J Pharmacol 1988; 147: 187-196