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Thromb Haemost 1995; 74(04): 1032-1034
DOI: 10.1055/s-0038-1649875
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

Plasminogen Activator Inhibitor-1 (PAI-1) Promoter Polymorphism and Coronary Artery Disease in Non-Insulin-Dependent Diabetes

Authors

  • Michael W Mansfield

    The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK

  • Max H Stickland

    The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK

  • Peter J Grant

    The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK
Further Information

Publication History

Received 30 March 1995

Accepted after resubmission 05 July 1995

Publication Date:
09 July 2018 (online)

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Summary

Elevated levels of PAI-1 are found in coronary artery disease (CAD) and non-insulin-dependent diabetes (NIDDM). PAI-1 may be involved in the pathogenesis of CAD through suppression of fibrinolysis, alternatively the high levels may result from vascular damage. There is evidence that PAI-1 levels are related to genotype at a PAI-1 promoter polymorphism. Genotype at this 4G/5G polymorphism was determined in 160 NIDDM (90 males and 70 females) patients with (n = 38) or without (n = 122) clinical evidence of CAD. Levels of cholesterol were higher (6.5 vs 5.9 mM, p <0.01) and of PAI-1 tended to be higher (PAI-1 activity 23.0 vs 20.4 U/ml) with CAD. The frequency of the 4G/4G genotype was increased and the 5G/5G genotype decreased, in the group CAD compared to those without (p <0.05). These results suggest that possession of the 4G/4G PAI-1 promoter genotype is a risk factor for the development of CAD in subjects with NIDDM.

 

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