Thromb Haemost 1992; 68(02): 130-135
DOI: 10.1055/s-0038-1656337
Original Article
Schattauer GmbH Stuttgart

Fibrin Gel Network Characteristics and Coronary Heart Disease: Relations to Plasma Fibrinogen Concentration, Acute Phase Protein, Serum Lipoproteins and Coronary Atherosclerosis

Kamaran Fatah
1   The Departments of Clinical Chemistry and Blood Coagulation, Stockholm, Sweden
,
Anders Hamsten
2   Internal Medicine, Karolinska Hospital, Stockholm, Sweden
3   King Gustaf V Research Institute, Stockholm, Sweden
,
Birger Blombäck
4   Department of Blood Coagulation Research, Karolinska Institute, Stockholm, Sweden
5   New York Blood Center, New York, NY, U.S.A.
,
Margareta Blombäck
1   The Departments of Clinical Chemistry and Blood Coagulation, Stockholm, Sweden
› Author Affiliations
Further Information

Publication History

Received 06 September 1991

Accepted after revision 06 March 1992

Publication Date:
03 July 2018 (online)

Summary

The native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of the hydrated fibrin gel networks in 18 men who had suffered a myocardial infarction before the age of 45 years and in 20 control subjects. Patients with an elevated plasma fibrinogen concentration had a considerably lower fibrin gel porosity (permeability coefficient, K s) compared with patients with a normal plasma fibrinogen level and with controls. The calculated fiber mass-length ratio of the fibrin gel networks was decreased in both patient groups. Gel porosity differed markedly between individuals at a given plasma fibrinogen concentration. Fairly strong inverse correlations were found between plasma orosomucoid level on the one hand and K s (r = –0.617, p <0.01) or fiber mass-length ratio (r = –0.499, p <0.05) on the other. The low density lipoprotein (LDL) cholesterol concentration also correlated inversely with K s (r = –0.471, p <0.05) and fiber mass-length ratio (r = –.522, p <0.05). Significant inverse relations, which were independent of plasma fibrinogen and lipoprotein concentrations, were detected between K s (r = –.519, p <0.05) and calculated fiber mass-length ratio (r = –.723, p <0.001) and number and severity of coronary artery stenoses determined by angiography. A proneness to formation of tight, rigid and space-filling fibrin network structures with small pores thus appears to be associated with premature coronary artery disease.