Acquired Factor XI Deficiency in Systemic Lupus erythematosus

G M Vercellotti; D F Mosher

doi:10.1055/s-0038-1657272

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1982; 48(03): 250-252
DOI: 10.1055/s-0038-1657272

Original Article

Schattauer GmbH Stuttgart

Acquired Factor XI Deficiency in Systemic Lupus erythematosus

G M Vercellotti

The Hematology Section, Dept. of Medicine, University of Minnesota, Minneapolis, Minnesota, U.S.A.

,

D F Mosher

¹Hematology Section, Dept. of Medicine, University of Wisconsin, Madison, Wis., U.S.A.

› Author Affiliations

Abstract

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Summary

A variety of coagulation abnormalities has been described in systemic lupus erythematosus (SLE). We report a unique SLE patient with an acquired factor XI deficiency. The low factor XI levels were not due to a classical coagulation inhibitor, but to a plasma factor (probably an immunoglobulin) that selectively bound factor XI. The factor XI deficiency improved after treatment with corticosteroids. Thus it is possible that in SLE immune complexes may bind clotting factors making them unavailable for use in the coagulation cascade.

Keywords

Factor XI - Systemic lupus erythematosus

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References

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