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Hamostaseologie 1992; 12(01): 001-006
DOI: 10.1055/s-0038-1660306
DOI: 10.1055/s-0038-1660306
Übersichtsarbeit/Review Articles
Lipoproteine und Thrombozyten
Further Information
Publication History
Publication Date:
26 June 2018 (online)
Zusammenfassung
Die Entstehung von Atherosklerose findet unter anderem ihren Ursprung in Läsionen des Endothels, die in Wechselwirkung mit aktivierten Thrombozyten, glatten Muskelzellen, Makrophagen, Wachstumsfaktoren, Lipoproteinen und Cholesterin zur Bildung atherosklerotischer Plaques führen können. Hohe Plasmakonzentrationen an Cholesterin, atherogenen Lipoproteinen, oxidativ modifizierten atherogenen Lipoproteinen sowie verminderte Plasmakonzentrationen an Antioxidanzien bedingen erhöhte Sensitivität und Reaktivität von Thrombozyten sowie gleichzeitig ein erhöhtes Risiko atherosklerotischer und kardiovaskulärer Veränderungen bei hyperlipämischen Patienten.
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