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Hamostaseologie 1992; 12(02): 047-051
DOI: 10.1055/s-0038-1660315
Übersichtsarbeit/Review Articles
Schattauer GmbH

Ist die intrakoronare Thrombolyse heute noch aktuell?

A. Vogt
1   Medizinische Klinik II, Städtische Kliniken Kassel (Direktor: Prof. Dr. K.-L. Neuhaus)
,
K.-L. Neuhaus
1   Medizinische Klinik II, Städtische Kliniken Kassel (Direktor: Prof. Dr. K.-L. Neuhaus)
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Publication History

Publication Date:
26 June 2018 (online)

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Zusammenfassung

Die intrakoronare Thrombolyse kann thrombotisch verschlossene Infarktgefäße zu einem hohen Prozentsatz rekanalisieren. Dies gelingt mit einer relativ geringen Gesamtdosis von Thrombolytika im Vergleich zur i.v. Gabe. Sie ist aber logistisch sehr aufwendig und kann nur einem Teil der Infarktpatienten zukommen. Zudem entsteht ein Zeitverlust von 40-60 Minuten gegenüber der i. v. Lyse, der durch die intrakoronar raschere Reperfusion nicht wettgemacht wird. Auch nach i. c. Lyse tritt ein globaler Gerinnungsdefekt ein, Blutungskomplikationen sind nicht nachweislich seltener als nach i. v. Kurzlyse. Beim akuten Herzinfarkt ist deshalb heute die i.v. Thrombolyse vorzuziehen.

Schlüsselwörter

Akuter Myokardinfarkt - thrombolyse - streptokinase

Keywords

Acute myocardial infarction - thrombolysis - streptokinase
 

  • LITERATUR

  • 1 Ambrose JA, Hjemdahl-Monsen C, Borrico S, Sherman W, Cohen M, Gorlin R, Fuster V. Quantitative and qualitative effects of intracoronary streptokinase in unstable angina and non-Q wave infarction. J Am Coll Cardiol 1987; 09: 1156-65.
    CrossrefPubMedGoogle Scholar
  • 2 Anderson JL, Rothbard RL, Hackworthy RA, Sorensen SG, Fitzpatrick PG, Dahl CF, Hagan AD, Browne KF, Symkoviak GP, Menlove RL, Barry WH, Eckerson HW, Marder VI. Multicenter reperfusion trial of intravenous anisoylated plasminogen streptokinase activator complex (APSAC) in acute myocardial infarction : controlled comparison with intracoronary streptokinase. J Am Coll Cardiol 1988; 11: 1153-63.
    CrossrefPubMedGoogle Scholar
  • 3 Blanke H, Schicha H, Cohen M, Kaiser H, Karsch KR, Neumann P, Rentrop KP. Long-term follow-up after intracoronary streptokinase therapy for acute myocardial infarction. Am Heart J 1985; 110: 736-42.
    CrossrefPubMedGoogle Scholar
  • 4 Bonnier HJ, Visser RF, Klomps HC, Hoffmann HJ. Comparison of intravenous anisoylated plasminogen streptokinase activator complex and intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1988; 62: 25-30.
    PubMedGoogle Scholar
  • 5 Burket MW, Smith MR, Walsh TE, Brewster PS, Fraker Jr TD. Relation of effectiveness of intracoronary thrombolysis in acute myocardial infarction to systemic thrombolytic state. Am J Cardiol 1985; 56: 441-44.
    CrossrefPubMedGoogle Scholar
  • 6 Cernigliaro C, Sansa M, Campi A, Bongo AS, Rossi P. Clinical experience with urokinase in intracoronary thrombolysis. Clin Cardiol 1987; 10: 222-30.
    CrossrefPubMedGoogle Scholar
  • 7 Chazov EL, Mateeva LS, Mazaev AV, Sargin KE, Sadovshaya M, Ruda Y. Intracoronary administration of fibrinolysis in acute myocardial infarction. Ter Arkh 1976; 48: 8-19.
    PubMedGoogle Scholar
  • 8 Collen D, Topol EJ, Tiefenbrunn AJ. Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial. Circulation 1984; 70: 1012-7.
    CrossrefPubMedGoogle Scholar
  • 9 DeWood MA, Spores J, Notske MD. et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 1980; 303: 897-902.
    CrossrefPubMedGoogle Scholar
  • 10 Essen von R, Uebis R, Schmidt W. et al. Intrakoronare Streptokinase beim akuten Herzinfarkt. Erfahrungen bei 461 Patienten. Dtsch Med Wochenschr 1985; 110: 570-5.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Ganz W, Geft I, Maddahi J, Berman D, Charuzi Y, Shah PK, Swan HJ. Nonsurgical reperfusion in evolving myocardial infarction. J Am Coll Cardiol 1983; 01: 1247-53.
    CrossrefPubMedGoogle Scholar
  • 12 GISSI (Gruppo Italiano per lo Studio della Streptochinasi nellTnfarto Miocardico). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986; I: 397-401.
    PubMedGoogle Scholar
  • 13 Gleichmann U, Mannebach H, Lichtlen P. 6. Bericht über Struktur und Leistungszahlen der Herzkatheterlabors in der Bundesrepublik Deutschland. Z Kardiol 1990; 79: 802-9.
    PubMedGoogle Scholar
  • 14 Gotoh K, Minamino T, Katoh O, Hamano Y, Fukui S, Hori M, Kusuoka H, Mishima M, Inoue M, Kamada T. The role of intracoronary thrombus in unstable angina: angiographic assessment and thrombolytic therapy during ongoing anginal attacks. Circulation 1988; 77: 526-34.
    CrossrefPubMedGoogle Scholar
  • 15 Haft JI, Goldstein JE, Homoud MK, Aaronoff M. PTC A following myocardial infarction: use of bailout fibrinolysis to improve results. Am Heart J 1990; 120: 243-7.
    CrossrefPubMedGoogle Scholar
  • 16 ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17187 cases of suspected acute myocardial infarction: ISIS 2. Lancet 1988; II: 349-60.
    PubMedGoogle Scholar
  • 17 Kambara H, Kammatsuse K, Nobuyoshi M, Kodama K, Sato H, Sasayama S, Kajiwara N, Nakashima M, Kawai C. Randomized double-blind trial of intracoronary urokinase for acute myocardial infarction : multicenter study. Jpn Cire J 1987; 51: 1072-6.
    CrossrefPubMedGoogle Scholar
  • 18 Kambara H, Kawai C, Kajiwara M. et al. Randomized double blind multicenter study. Comparison of intracoronary singlechain urokinase-type plasminogen activator, pro-urokinase (GE 0943), and intracoronary urokinase in patients with acute myocardial infarction. Circulation 1988; 78: 899-905.
    CrossrefPubMedGoogle Scholar
  • 19 Kasper W, Erbel R, Meinertz T, Drexler M, Rückei A, Pop T, Prellwitz W, Meyer J. Intracoronary thrombolysis with an acylated streptokinase plasminogen activator (BRL 26921) in patients with acute myocardial infarction. J Am Coll Cardiol 1984; 04: 357-63.
    CrossrefPubMedGoogle Scholar
  • 20 Kennedy JW. Streptokinase for the treatment of acute myocardial infarction: a brief review of randomized trials. J Am Coll Cardiol 1987; 05: 28B-32B.
    PubMedGoogle Scholar
  • 21 Kennedy JW, Gensini GG, Timmis GC, Maynard C. Acute myocardial infarction treated with intracoronary streptokinase: a report of the society for cardiac angiography. Am J Cardiol 1985; 55: 871-7.
    CrossrefPubMedGoogle Scholar
  • 22 Kennedy JW, Ritchie JL, Davis KB, Fritz JK. Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 1983; 309: 1477-82.
    CrossrefPubMedGoogle Scholar
  • 23 Kennedy JW, Ritchie JL, Davis KB, Stadius ML, Maynard C, Fritz JK. The Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. A 12-month follow-up report. N Engl J Med 1985; 312: 1073-8.
    CrossrefPubMedGoogle Scholar
  • 24 Laffel GL, Braunwald E. Thrombolytic therapy, a new strategy for the treatment of acute myocardial infarction (two parts). N Engl J Med 1984; 311: 710-7-770-6.
    PubMedGoogle Scholar
  • 25 Lew AS, Laramee P, Cercek B, Rodriguez L, Ganz W. Thrombolytic therapy with intracoronary or intravenous streptokinase during acute myocardial infarction. Z Kardiol 1985; 74 (Suppl 6): 129-34.
    PubMedGoogle Scholar
  • 26 Lo YSA. Intravenous versus intracoronary streptokinase in acute myocardial infarction. Clin Cardiol 1985; 08: 609-19.
    CrossrefPubMedGoogle Scholar
  • 27 Lurie AA, Rogers WJ, Gross LF. Coagulation and fibrinolytic changes in evolving myocardial infarction treated by high-dose, brief-duration intracoronary or intravenous streptokinase. Am J Clin Pathol 1990; 93: 246-51.
    CrossrefPubMedGoogle Scholar
  • 28 Motomiya T, Tokuyasu Y, Watanabe K, Sakurada H, Ejiri N, Yanase O. Intracoronary urokinase in acute myocardial infarction : prevalence of total coronary occlusion during the early hours, effects on myocardial infarct size and left ventricular function, and outcome of residual coronary stenosis. Jpn Cire J 1988; 52: 702-8.
    CrossrefPubMedGoogle Scholar
  • 29 Nakagawa S, Hanada Y, Koiwaya Y, Tanaka K. Angiographic features in the infarctrelated artery after intracoronary urokinase followed by prolonged anticoagulation. Role of ruptured atheromatous plaque and adherent thrombus in acute myocardial infarction in vivo. Circulation 1988; 78: 1335-44.
    CrossrefPubMedGoogle Scholar
  • 30 Natarajan D, Rai VN, Jain A, Roy T, Sharma PK, Nigam PD. Intracoronary versus intravenous streptokinase in acute myocardial infarction. Int J Cardiol 1988; 19: 181-9.
    CrossrefPubMedGoogle Scholar
  • 31 Neuhaus KL, Feuerer W, Jeep-Tebbe S, Niederer W, Vogt A, Tebbe U. Improved thrombolysis with a modified dose regimen of recombinant tissue-type plasminogen activator. J Am Coll Cardiol 1989; 14: 1566-9.
    CrossrefPubMedGoogle Scholar
  • 32 Neuhaus KL, Köstering H, Tebbe U, Sauer G, Kreuzer H. Intravenöse Kurzzeitstreptokinase-Therapie beim frischen Myokardinfarkt. Z Kardiol 1981; 70: 791-6.
    PubMedGoogle Scholar
  • 33 Neuhaus KL, Tebbe U, Gottwik M, Weber MAJ, Feuerer W, Niederer W, Harer W, Praetorius F, Grosser KD, Huhmann W, Hoepp HW, Alber G, Sheikhzadeh A, Schneider B. Intravenous recombinant tissue plasminogen activator (rt-PA) and urokinase in acute myocardial infarction: results of the german activator urokinase study (GAUS). J Am Coll Cardiol 1988; 12: 581-7.
    CrossrefPubMedGoogle Scholar
  • 34 Ohyagi A, Hirose K, Watanabe Y, Nakai T, Tsujimoto S, Doyama K, Suzuki Y, Okazaki S, Hirai M. Dose of urokinase for intracoronary thrombolysis in patients with acute myocardial infarction. Clin Cardiol 1987; 10: 453-6.
    CrossrefPubMedGoogle Scholar
  • 35 Patel B, Kloner RA. Analysis of reported randomized trials of streptokinase therapy for acute myocardial infarction in the 1980s. Am J Cardiol 1987; 59: 501-4.
    CrossrefPubMedGoogle Scholar
  • 36 Pavlides GS, Schreiber TL, Gangadharan V, Puchrowicz S, O’Neill WW. Safety and efficacy of urokinase during elective coronary angioplasty. Am Heart J 1991; 121: 731-7.
    CrossrefPubMedGoogle Scholar
  • 37 Raizner AE, Tortoledo FA, Verani MS. et al. Intracoronary thrombolytic therapy in acute myocardial infarction: a prospective, randomized, controlled trial. Am J Cardiol 1985; 55: 301-8.
    CrossrefPubMedGoogle Scholar
  • 38 Rentrop P, Blanke H, Karsch KR, Kaiser H, Köstering H, Leitz K. Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris. Circulation 1981; 63: 307-12.
    CrossrefPubMedGoogle Scholar
  • 39 Rentrop P, Blanke H, Köstering K. et al. Acute myocardial infarction: intracoronary application of nitroglycerine and streptokinase in combination with transluminal recanalization. Clin Cardiol 1979; 05: 354-63.
    PubMedGoogle Scholar
  • 40 Rentrop P, Feit F, Blanke H. et al. Effects of intracoronary streptokinase and intracoronary nitroglycerin infusion on coronary angiographic patterns and mortality in patients with acute myocardial infarction. N Engl J Med 1984; 311: 1457-63.
    CrossrefPubMedGoogle Scholar
  • 41 Rothbard RL, Anderson JL, Fitzpatrick PG, Hackworthy RA, Sorensen SG, Marder VJ. Tolerance and complications in a multicenter trial of intravenous APSAC and intracoronary streptokinase in acute myocardial infarction. Clin Cardiol 1990; Suppl 5 (VII-4): V27-32.
    PubMedGoogle Scholar
  • 42 Rothbard RL, Fitzpatrick PG, Francis CW, Caton DM, Hood Jr WB, Marder VJ. Relationship of the lytic state to successful reperfusion with standardand low-dose intracoronary streptokinase. Circulation 1985; 71: 562-70.
    CrossrefPubMedGoogle Scholar
  • 43 Samaha JK, Quigley P, Kereiakes DJ, Griffin B, Stack RS, Sigmon K, Candela R, Califf RM, Topol EJ. Intracoronary thrombolytic therapy in patients with refractory thrombus after intravenous treatment. J Am Coll Cardiol 1989; 13 (Suppl): 92A.
    CrossrefPubMedGoogle Scholar
  • 44 Schiemann G, Cohen BM, Kozina J, Erickson JS, Podolin RA, Peterson KL, Ross jr J, Buchbinder M. Intracoronary urokinase for intracoronary thrombus accumulation complicating percutaneous transluminal coronary angioplasty in acute ischemic syndromes. Circulation 1990; 82: 2052-60.
    CrossrefPubMedGoogle Scholar
  • 45 Schreiber T. Review of clinical studies of thrombolytic agents in acute myocardial infarction. Am J Med 1987; 83 (Suppl 2A): 20-5.
    PubMedGoogle Scholar
  • 46 Schröder R, Biamino G, Enz-Rüdiger VL. et al. Intravenous short-term infusion of streptokinase in acute myocardial infarction. Circulation 1983; 67: 536-48.
    CrossrefPubMedGoogle Scholar
  • 47 Simoons ML, van der Brand M, de Zwaan C. et al. Improved survival after early thrombolysis in acute myocardial infarction. Lancet 1985; II: 578-81.
    PubMedGoogle Scholar
  • 48 Six AJ, Brommer EJ, Mueller EJ, Kerkhoff HF. Activation of the fibrinolytic system during intracoronary streptokinase administration. J Am Coll Cardiol 1987; 09: 189-96.
    CrossrefPubMedGoogle Scholar
  • 49 Smalling RW, Fuentes F, Matthews MW, Kuhn J, Nishikawa A, Walker WE, Adams PR, Gould KL. Factors affecting outcome of coronary reperfusion with intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1987; 59: 505-12.
    CrossrefPubMedGoogle Scholar
  • 50 Spann JF, Sherry S, Carabello BA. et al. Coronary thrombolysis by intravenous streptokinase in acute myocardial infarction: acute and follow-up studies. Am J Cardiol 1984; 53: 655-61.
    CrossrefPubMedGoogle Scholar
  • 51 Stampfer MJ, Goldhaber SZ, Yusuf S, Peto R, Hennekens CH. Effect of intravenous streptokinase on acute myocardial infarction. Pooled results from randomized trials. N Engl J Med 1980; 307: 1180-2.
    PubMedGoogle Scholar
  • 52 Tebbe U, Herrmann KS. Dosierung der intrakoronaren Urokinase-Infusion beim akuten Myokardinfarkt. Klin Wochenschr 1988; 66: 1193-5.
    CrossrefPubMedGoogle Scholar
  • 53 TIMI Study Group. The thrombolysis in myocardial infarction (TIMI) trial. N Engl I . Med 1985; 312: 932-6.
    PubMedGoogle Scholar
  • 54 Valentine RP, Pitts DE, Brooks-Brunn JA, Williams JG, Van Hove E, Schmidt PE. Intravenous versus intracoronary streptokinase in acute myocardial infarction. Am J Cardiol 1985; 55: 309-12.
    CrossrefPubMedGoogle Scholar
  • 55 Verheugt FW, van Eeenige MJ, Res JC, Simoons ML, Serruys PW, Vermeer F, van Hoogenhuyze DC, Remme PJ, de Zwaan C, Baer F. Bleeding complications of intracoronary fibrinolytic therapy in acute myocardial infarction. Assessment of risk in a randomised trial. Br Heart J 1985; 54: 455-9.
    CrossrefPubMedGoogle Scholar
  • 56 Verna E, Repetto S, Boscarini M, Onofri M, Qing LG, Binaghi G. Management of complicated coronary angioplasty by intracoronary urokinase and immediate re-angioplasty. Cathet Cardiovasc Diagn 1990; 19: 116-22.
    CrossrefPubMedGoogle Scholar
  • 57 Verstraete M, Bory M, Collen D, Erbel R, Lennane RJ, Mathey D, Michels HR, Schartl M, Uebis R, Bernard R, Brower RW, DeBono DP, Huhmann W, Lubsen J, Meyer J, Rutsch W, Schmidt W, von Essen R. Randomised trial of intravenous recombinant tissue-type plasminogen activator versus intravenous streptokinase in acute myocardial infarction. Report from the European cooperative study group for recombinant tissue-type plasminogen activator. Lancet 1985; I: 842-7.
    PubMedGoogle Scholar
  • 58 Weinstein J. The international registry to support approval of intracoronary streptokinase thrombolysis in the treatment of myocardial infarction. Assessment of safety and efficacy. Circulation 1983; 68 (2 Pt 2): 161-6.
    PubMedGoogle Scholar
  • 59 Werf van de F, Ludbrook PA, Bergmann SR, Tiefenbrunn AJ, Fox KAA, Geest de H, Verstraete M, Collen D, Sobel BE. Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction. N Engl J Med 1984; 310: 609-13.
    CrossrefPubMedGoogle Scholar
  • 60 Yusuf S, Collins R, Peto R, Furberg C, Stampfer MJ, Goldhaber SZ, Hennekens CH. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction : overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J 1985; 06: 556-85.
    CrossrefPubMedGoogle Scholar