Diffuse Loss of Vertebral Body Height and Marrow Changes in a 4-Year-Old with Acute Lymphoblastic Leukemia

Abstract

Acute leukemia can present with a wide range of symptoms and with no classic osseous findings on radiographs. Recognizing subtle imaging abnormalities and raising the possibility of a lymphoproliferative or hematologic pathology may facilitate early diagnosis. Described here is a case of a 4-year-old with back pain that was found to have acute lymphoblastic leukemia with diffuse loss of vertebral body height on plain film radiographs, and with prominent discs, and diffusely abnormal marrow signal on magnetic resonance imaging.

Keywords

acute lymphoblastic leukemia - vertebral body height loss - pediatric bone marrow signal abnormalities

• References

• 1 Ulu EM, Töre HG, Bayrak A, Güngör D, Coşkun M. MRI of central nervous system abnormalities in childhood leukemia. Diagn Interv Radiol 2009; 15 (02) 86-92
• 2 Shahnazi M, Khatami A, Shamsian B, Haerizadeh B, Mehrafarin M. Bony lesions in pediatric acute leukemia: pictorial essay. Iran J Radiol 2012; 9 (01) 50-56
• 3 Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environ Health Perspect 2007; 115 (01) 138-145
• 4 Clarke RT, Van den Bruel A, Bankhead C, Mitchell CD, Phillips B, Thompson MJ. Clinical presentation of childhood leukaemia: a systematic review and meta-analysis. Arch Dis Child 2016; 101 (10) 894-901
• 5 Nadler LM, Korsmeyer SJ, Anderson KC. , et al. B cell origin of non-T cell acute lymphoblastic leukemia. A model for discrete stages of neoplastic and normal pre-B cell differentiation. J Clin Invest 1984; 74 (02) 332-340
• 6 Sinigaglia R, Gigante C, Bisinella G, Varotto S, Zanesco L, Turra S. Musculoskeletal manifestations in pediatric acute leukemia. J Pediatr Orthop 2008; 28 (01) 20-28
• 7 Geetha N, Sreelesh KP, Priya MJ, Lali VS, Rekha N. Osteolytic bone lesions - a rare presentation of AML M6. Mediterr J Hematol Infect Dis 2015; 7 (01) e2015017 . doi: 10.4084/MJHID.2015.017