Thorac cardiovasc Surg 2019; 67(08): 688-691
DOI: 10.1055/s-0038-1675346
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

Near-Infrared Imaging Using Intravenous Indocyanine Green at a Conventional Dose to Locate Pulmonary Metastases: A Pilot Study

Masatsugu Hamaji
1  Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan
,
Toyofumi Fengshi Chen-Yoshikawa
1  Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan
,
Manabu Minami
2  Department of Clinical Innovative Medicine, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan
,
Hiroshi Date
1  Department of Thoracic Surgery, Kyoto University Hospital, Kyoto University, Sakyo-ku, Kyoto, Japan
› Author Affiliations
Funding Partially supported by the research grant from the Japanese Foundation for Research and Promotion of Endoscopy.
Further Information

Publication History

27 April 2018

10 October 2018

Publication Date:
02 November 2018 (online)

Abstract

Intravenous indocyanine green (ICG) has been reported to localize intra-abdominal metastatic lesions in several clinical trials. Our pilot study aimed to investigate the feasibility and safety of ICG fluorescence localization in pulmonary metastasectomy using a near-infrared fluorescence thoracoscope. Each patient received intravenous 0.25 or 0.5 mg/kg of ICG. The maximum diameter of the tumor on computed tomography ranged from 0.5 to 3.5 (median: 1.15) cm. Intravenous ICG injection localized pulmonary metastases in a portion (3 patients) of the enrolled patients. Our preliminary results provided us with important information to modify the study protocol.