Endoscopy 2019; 51(04): S20
DOI: 10.1055/s-0039-1681227
ESGE Days 2019 oral presentations
Friday, April 5, 2019 08:30 – 10:30: EUS diagnosis Club D
Georg Thieme Verlag KG Stuttgart · New York

CLINICAL PERFORMANCE OF NEW THREE POINTS 19 G ENDOSCOPIC ULTRASOUND CORE NEEDLE FOR THE HISTOLOGICAL DIAGNOSIS OF MESENCHYMAL TUMORS

G Delconte
1   Diagnostic and Therapeutic Endoscopy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
,
F Cavalcoli
1   Diagnostic and Therapeutic Endoscopy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
,
P Collini
2   Sarcoma Unit, Surgery Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
,
S Pasquali
3   Pathology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
,
A Magarotto
1   Diagnostic and Therapeutic Endoscopy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
,
E Masci
1   Diagnostic and Therapeutic Endoscopy Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
› Author Affiliations
Further Information

Publication History

Publication Date:
18 March 2019 (online)

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Aims:

Different type and size of histological needles for endoscopic ultrasound guided fine needle biopsies (EUS-FNB) have been developed, however their best application has to be defined. The diagnosis of mesenchymal tumors (MT) often requires tissue for molecular studies (i.e. ISH. FISH, NGS) beside H&E and immunohistochemistry. Aim of the study was to evaluate the clinical performance of a new three-points 19 G core needle in MT.

Methods:

From July 2017 to October 2018, all the consecutive patients who underwent EUS-FNB at a single referral with a three-points19 G core needle for suspected abdominal MT, were prospectively analyzed. Gross visual inspection was performed to determine the number of passes.

Results:

26 patients were evaluated. The procedure was technically feasible in all cases. Five patients were excluded due to diagnosis of other malignancies. The remaining 21 patients were diagnosed with MT (17 males, mean age 51 ± 18.2 years). Based on groß visual inspection a mean number of 1.3 passes (range 1 – 2) were performed without major adverse events. The diagnosis was established by FNB in 20 cases (accuracy 95.2%). Final diagnosis were GIST in 10 cases, sarcoma in 3, leiomyoma in 2, angiomixoma, schwannoma, glioma, and desmoid-type fibromatosis in one case each. The mean size of the lesions was 77 mm (range 25 – 190). FNB was non-diagnostic in a patient with a large mass with lipomatous radiological features. Pathological examination showed adequate material for full histological and molecular diagnosis at the first pass in 19/20 cases.

Conclusions:

This is the first report on new three-points design 19 G histological EUS needle. In the setting of MT this needle showed high feasibility and safety with a high-rate of core tissue in the specimen allowing full histological and molecular evaluations. These evidences support this device as a promising tool when a histological diagnosis is needed as in case of MT.