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DOI: 10.1055/s-0039-1681918
ASSOCIATION OF PROTON PUMP INHIBITORS WITH RISK OF DEMENTIA: A NATIONWIDE POPULATION-BASED COHORT STUDY IN SOUTH KOREA
Publication History
Publication Date:
18 March 2019 (online)
Aims:
The present study was performed to investigate the association between PPI use and dementia using the Korean National Health Insurance Service (KNHIS), to follow the development of dementia in users and non-users of PPIs in a Korean population over a > 10-year period (2002 – 2013).
Methods:
We used a retrospective, case-control design in which both cases and controls had exposure to a new PPI prescription and from which a definite period (12 months) of observation was accrued from the first PPI dispensing date until the onset of dementia or December 31, 2013.
Results:
These observations indicated that the PPI cohort had a significantly elevated risk of dementia compared to the control cohort (IRR: 1.34, 95% CI: 1.24 – 1.43). Subgroup analysis revealed similarly elevated risks of dementia in the PPI cohort for most variables. The risk of dementia in the PPI cohort increased at all ages, but risk ratio compared with the controls decreased with age, and there was no difference among subjects in their 80 s or older. The risk of dementia in the PPI cohort increased at all levels of household income and was increased in the low household income in both the PPI cohort and controls. The PPI cohort showed increased risk of dementia for all comorbidities.
Conclusions:
In our retrospective cohort study from the National Health Insurance Database of Korea, the risk of all-cause dementia was shown to be significantly associated with PPI use over 90 DDD, as compared to a matched control group.