CC BY-NC-ND 4.0 · Journal of Gastrointestinal and Abdominal Radiology 2019; 02(02): 078-086
DOI: 10.1055/s-0039-1691846
Review Article
Indian Society of Gastrointestinal and Abdominal Radiology

NSAID Enteropathy: A Review of the Disease Entity and Its Distinction from Crohn’s Enteropathy

Smita Esther Raju
1  Department of Radiology, Royal Adelaide Hospital, Adelaide, Australia
Rajvinder Singh
2  Department of Gastroenterology, Lyell McEwin Hospital, South Australia
Mahima Raju
3  School of Medicine, University of Adelaide, North Terrace, Adelaide, South Australia
› Author Affiliations
Further Information

Publication History

Received: 29 August 2018

Accepted after revision: 01 March 2019

Publication Date:
17 July 2019 (online)



Nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy is an increasingly recognized entity. Patients of older age and those suffering from conditions such as arthritis requiring long term NSAIDs are thought to be at greater risk. Introduction of enteroscopic techniques has greatly improved understanding of NSAID-related small intestinal injury. Complementary high-resolution cross-sectional imaging techniques aid in initial evaluation and for exclusion of alternative etiology. Erosions, superficial ulcerations, and short segment strictures are the most commonly described findings. The diagnosis of the condition lies in obtaining relevant history in addition to a high degree of suspicion during investigation of anemia, obscure gastrointestinal bleeding, small bowel obstruction, and protein losing enteropathy. Herein, the authors present a review of pathogenesis and imaging findings of NSAID enteropathy with particular emphasis on distinction from Crohn’s enteropathy.