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CC BY-NC-ND 4.0 · AJP Rep 2019; 09(03): e275-e291
DOI: 10.1055/s-0039-1695004
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

Hui Qing Lu 
1   Department of Obstetrics, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China
,
Rong Hu
1   Department of Obstetrics, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China
› Author Affiliations Funding Information This study was supported by the National Natural Science Foundation of China 81571460.
Further Information

Publication History

21 December 2018

12 March 2019

Publication Date:
10 September 2019 (online)

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Abstract

Preeclampsia is a common pregnancy complication which can have adverse impact on both mother and baby. In addition to the short term effects, a large body of epidemiological evidence has found preeclampsia can exert long-lasting effects on mother and offspring. Studies suggest that offspring exposed to preeclampsia are at a higher risk of developing cardiovascular, metabolic, and neurological diseases, as well as other diseases. However, studies investigating the underlying mechanism are limited, the exact mechanism still remains unclear. In this study, we will review the epidemiological evidence and studies exploring the mechanism underlying long-term effects of preeclampsia on offspring. Further studies should be targeted at this field so as to implement effective clinical management to prevent the exposed offspring from potential diseases.

Keywords

Preeclampsia Offspring - cardiovascular system - neurological disorders - metabolism - DOHaD
 

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