Study on Use of Platelet-Rich Plasma in Myringoplasty
30 September 2019 (online)
Introduction Success rate after myringoplasty has a wide range from 70 to 80%. Therefore, there is still a need to search for methods to enhance tympanic membrane healing after myringoplasty to increase success rate. In our study, we have compared the use of platelet-rich plasma (PRP) in myringoplasty. The platelets are best known for their importance in clotting blood. However, platelets also contain hundreds of proteins called growth factors which are very important in the healing of injuries. PRP is plasma with many more platelets than what is typically found in blood. The concentration of platelets and, thereby, the concentration of growth factors can be 5 to 10 times greater (or richer) than usual. The study focuses on the use of prepared autologous PRP which is kept on the lateral surface of graft and TM remnant postmyringoplasty and results were noted with respect to the uptake of graft in such patients.
Aim To assess the topical use of autologous PRP to improve success rate of myringoplasty.
Objectives To compare pre- and postoperative graft uptake and audiological benefit, following myringoplasty with and without PRP.
Methods Patients were diagnosed cases of chronic suppurative otitis media tubotympanic type who were divided into groups of 35 each. Patients in first group underwent myringoplasty with PRP, while those in second group underwent myringoplasty without PRP. Pre- and postoperative graft status and pure tone audiometry were performed for all the patients and the outcomes were compared.
Results Out of 35 patients in each group, four in the study group and eight in the control group had residual perforation. Graft uptake in case group was 88.57% and graft uptake in the control group was 77.1%. Result was better in cases that underwent myringoplasty with PRP. Out of 35 patients in case group, audiological improvement (> 10 dB) was seen in 31 patients (88.57%); in the control group of 35 patients, 27 (77.1%) had audiological benefits.
Conclusion This study shows there is definite benefit by using PRP in myringoplasty. As the PRP can be easily prepared, PRP myringoplasty can be routinely performed.