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CC BY-NC-ND 4.0 · Int Arch Otorhinolaryngol 2020; 24(03): e308-e312
DOI: 10.1055/s-0039-3399541
Original Research
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

25-Hydroxyl Vitamin D Deficiency in Nasal Polyposis

Ankur Kumar Chandrakar
1   Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
,
Arun Alexander 
1   Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
,
Medha R.
2   Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
,
Kalaiselvi Rajendiran
2   Department of Biochemistry, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
,
Karthikeyan Ramasamy
1   Department of ENT, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India
› Author Affiliations Funding JIPMER INTRAMURAL FUND, (Grant / Award Number: 'JIP/Res/Intra-MD/MS/01/2014')
Further Information

Publication History

17 July 2019

24 September 2019

Publication Date:
13 December 2019 (online)

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Abstract

Introduction Vitamin D is known to have immunomodulatory functions and has action on chronic inflammatory processes, such as nasal polyposis.

Objective The present study assessed the levels of 25-hydroxy vitamin D and high-sensitivity C-reactive protein (hs-CRP) in patients with nasal polyposis, as compared with healthy control subjects, and identified their association with disease severity in nasal polyposis. It further assessed the levels of 25-hydroxyl vitamin D and hs-CRP in patients with nasal polyposis and atopy and compared it with patients with nasal polyposis without atopy.

Methods This was a cross-sectional study involving 2 groups: 80 patients with nasal polyposis and 80 healthy subjects. In patients with nasal polyposis, the disease severity is assessed by the sino-nasal outcome test (SNOT20) and by the Lund & Mackay staging system. Levels of 25-hydroxy vitamin D and hs-CRP were measured by enzyme-linked immunosorbent assay (ELISA).

Result The mean 25-hydroxyl vitamin D levels (ng/ml) was 12.01 ± 7.29 for cases and 22.87 ± 14.95 for controls, with p < 0.0001. The mean hs-CRP levels (mg/L) was 5.99 ± 2.74 in cases and 2.41 ± 1.95 in controls, with p < 0.0001. The severity of polyposis correlated negatively with serum levels of 25-hydroxy vitamin D and positively with hs-CRP.

Conclusion The study has thus shown significant correlation between vitamin D deficiency and inflammation in patients with nasal polyps.

Keywords

Vitamin D - hs-CRP - nasal polyposis
 

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