Digestive Disease Interventions 2019; 03(04): 295-304
DOI: 10.1055/s-0039-3400493
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Endoscopic Management of Biliary Complications after Liver Transplant

Ali Akram
1   Division of Gastroenterology, Department of Medicine, University of California San Diego Health Sciences, San Diego, California
,
Robert Klapheke
1   Division of Gastroenterology, Department of Medicine, University of California San Diego Health Sciences, San Diego, California
,
Wilson Kwong
1   Division of Gastroenterology, Department of Medicine, University of California San Diego Health Sciences, San Diego, California
› Author Affiliations
Further Information

Publication History

28 February 2019

15 October 2019

Publication Date:
27 November 2019 (online)

Abstract

Orthotropic liver transplant (OLT) is the definitive treatment for patients with end stage liver disease of all etiologies. Biliary complications are common after OLT and living donor liver transplant (LDLT). Approximately, 15% of patients undergoing deceased donor liver transplant develop strictures and this number is even higher in LDLT recipients (28–32%).[1] [2] Common biliary complications include anastomotic and non-anastomotic strictures, bile leaks, biliary casts, and stones.[3] Endoscopic therapy has become the mainstay of management of these biliary conditions. Endoscopic therapy involves sphincterotomy, dilation, and stent deployment to maintain patency of the bile duct and provide adequate drainage. This article will review current literature regarding endoscopic management of biliary complications after liver transplant and discuss recent endoscopic advances that can reduce the need for reoperation.

Disclosures

None.


 
  • References

  • 1 Arain MA, Attam R, Freeman ML. Advances in endoscopic management of biliary tract complications after liver transplantation. Liver Transpl 2013; 19 (05) 482-498
  • 2 Akamatsu N, Sugawara Y, Hashimoto D. Biliary reconstruction, its complications and management of biliary complications after adult liver transplantation: a systematic review of the incidence, risk factors and outcome. Transpl Int 2011; 24 (04) 379-392
  • 3 Ayoub WS, Esquivel CO, Martin P. Biliary complications following liver transplantation. Dig Dis Sci 2010; 55 (06) 1540-1546
  • 4 Koneru B, Sterling MJ, Bahramipour PF. Bile duct strictures after liver transplantation: a changing landscape of the Achilles' heel. Liver Transpl 2006; 12 (05) 702-704
  • 5 Kienlein S, Schoening W, Andert A, Kroy D, Neumann UP, Schmeding M. Biliary complications in liver transplantation: impact of anastomotic technique and ischemic time on short- and long-term outcome. World J Transplant 2015; 5 (04) 300-309
  • 6 Kochhar G, Parungao JM, Hanouneh IA, Parsi MA. Biliary complications following liver transplantation. World J Gastroenterol 2013; 19 (19) 2841-2846
  • 7 Seehofer D, Eurich D, Veltzke-Schlieker W, Neuhaus P. Biliary complications after liver transplantation: old problems and new challenges. Am J Transplant 2013; 13 (02) 253-265
  • 8 Zemel G, Zajko AB, Skolnick ML, Bron KM, Campbell WL. The role of sonography and transhepatic cholangiography in the diagnosis of biliary complications after liver transplantation. AJR Am J Roentgenol 1988; 151 (05) 943-946
  • 9 Xu YB, Min ZG, Jiang HX, Qin SY, Hu BL. Diagnostic value of magnetic resonance cholangiopancreatography for biliary complications in orthotopic liver transplantation: a meta-analysis. Transplant Proc 2013; 45 (06) 2341-2346
  • 10 Akbar A, Tran QT, Nair SP. , et al. Role of MRCP in diagnosing biliary anastomotic strictures after liver transplantation: a single tertiary care center experience. Transplant Direct 2018; 4 (05) e347
  • 11 Costamagna G, Pandolfi M, Mutignani M, Spada C, Perri V. Long-term results of endoscopic management of postoperative bile duct strictures with increasing numbers of stents. Gastrointest Endosc 2001; 54 (02) 162-168
  • 12 Zoepf T, Maldonado-Lopez EJ, Hilgard P. , et al. Balloon dilatation vs. balloon dilatation plus bile duct endoprostheses for treatment of anastomotic biliary strictures after liver transplantation. Liver Transpl 2006; 12 (01) 88-94
  • 13 Kulaksiz H, Weiss KH, Gotthardt D. , et al. Is stenting necessary after balloon dilation of post-transplantation biliary strictures? Results of a prospective comparative study. Endoscopy 2008; 40 (09) 746-751
  • 14 Costamagna G, Tringali A, Mutignani M. , et al. Endotherapy of postoperative biliary strictures with multiple stents: results after more than 10 years of follow-up. Gastrointest Endosc 2010; 72 (03) 551-557
  • 15 Tringali A, Barbaro F, Pizzicannella M. , et al. Endoscopic management with multiple plastic stents of anastomotic biliary stricture following liver transplantation: long-term results. Endoscopy 2016; 48 (06) 546-551
  • 16 Dai SC, Goldberg D, Agarwal A. , et al. Endoscopic therapy is effective for recurrent anastomotic biliary strictures after orthotopic liver transplantation. Ann Hepatol 2017; 16 (06) 924-931
  • 17 Martins FP, De Paulo GA, Contini MLC, Ferrari AP. Metal versus plastic stents for anastomotic biliary strictures after liver transplantation: a randomized controlled trial. Gastrointest Endosc 2018; 87 (01) 131.e1-131.e13
  • 18 Tal AO, Finkelmeier F, Filmann N. , et al. Multiple plastic stents versus covered metal stent for treatment of anastomotic biliary strictures after liver transplantation: a prospective, randomized, multicenter trial. Gastrointest Endosc 2017; 86 (06) 1038-1045
  • 19 Kaffes A, Griffin S, Vaughan R. , et al. A randomized trial of a fully covered self-expandable metallic stent versus plastic stents in anastomotic biliary strictures after liver transplantation. Therap Adv Gastroenterol 2014; 7 (02) 64-71
  • 20 Coté GA, Slivka A, Tarnasky P. , et al. Effect of covered metallic stents compared with plastic stents on benign biliary stricture resolution: a randomized clinical trial. JAMA 2016; 315 (12) 1250-1257
  • 21 Visconti TAC, Bernardo WM, Moura DTH. , et al. Metallic vs plastic stents to treat biliary stricture after liver transplantation: a systematic review and meta-analysis based on randomized trials. Endosc Int Open 2018; 6 (08) E914-E923
  • 22 Kato H, Kawamoto H, Tsutsumi K. , et al. Long-term outcomes of endoscopic management for biliary strictures after living donor liver transplantation with duct-to-duct reconstruction. Transpl Int 2009; 22 (09) 914-921
  • 23 Chang JH, Lee I, Choi MG, Han SW. Current diagnosis and treatment of benign biliary strictures after living donor liver transplantation. World J Gastroenterol 2016; 22 (04) 1593-1606
  • 24 Chok KS, Lo CM. Systematic review and meta-analysis of studies of biliary reconstruction in adult living donor liver transplantation. ANZ J Surg 2017; 87 (03) 121-125
  • 25 Krok KL, Cárdenas A, Thuluvath PJ. Endoscopic management of biliary complications after liver transplantation. Clin Liver Dis 2010; 14 (02) 359-371
  • 26 Lee YY, Gwak GY, Lee KH. , et al. Predictors of the feasibility of primary endoscopic management of biliary strictures after adult living donor liver transplantation. Liver Transpl 2011; 17 (12) 1467-1473
  • 27 Kim ES, Lee BJ, Won JY, Choi JY, Lee DK. Percutaneous transhepatic biliary drainage may serve as a successful rescue procedure in failed cases of endoscopic therapy for a post-living donor liver transplantation biliary stricture. Gastrointest Endosc 2009; 69 (01) 38-46
  • 28 Seo JK, Ryu JK, Lee SH. , et al. Endoscopic treatment for biliary stricture after adult living donor liver transplantation. Liver Transpl 2009; 15 (04) 369-380
  • 29 Elwir S, Thompson J, Amateau SK. , et al. Endoscopic management of biliary leaks and strictures after living donor liver transplantation: optimizing techniques for successful management. Dig Dis Sci 2017; 62 (01) 244-252
  • 30 Jang S, Parsi MA, Lopez R, Bhatt A, Vargo JJ. Efficacy and optimal duration of metallic stent in the management of refractory anastomotic stricture after liver transplantation. Clin Gastroenterol Hepatol 2017; 15 (11) 1776-1781
  • 31 Maheshwari A, Maley W, Li Z, Thuluvath PJ. Biliary complications and outcomes of liver transplantation from donors after cardiac death. Liver Transpl 2007; 13 (12) 1645-1653
  • 32 Kowdley KV, Fawaz KA, Kaplan MM. Extrahepatic biliary stricture associated with cytomegalovirus in a liver transplant recipient. Transpl Int 1996; 9 (02) 161-163
  • 33 Fujikawa T, Fujita S, Mekeel KL. , et al. Effect of early recurrence of hepatitis C on late biliary anastomotic stricture after liver transplantation. Transplant Proc 2006; 38 (10) 3661-3662
  • 34 Thuluvath PJ, Pfau PR, Kimmey MB, Ginsberg GG. Biliary complications after liver transplantation: the role of endoscopy. Endoscopy 2005; 37 (09) 857-863
  • 35 Tsujino T, Isayama H, Kogure H, Sato T, Nakai Y, Koike K. Endoscopic management of biliary strictures after living donor liver transplantation. Clin J Gastroenterol 2017; 10 (04) 297-311
  • 36 Barbaro F, Tringali A, Baldan A. , et al. Endoscopic management with plastic stents of nonanastomotic biliary strictures following liver transplantation: a single center experience. Endoscopy 2018; 50: S71
  • 37 Lee HW, Shah NH, Lee SK. An update on endoscopic management of post-liver transplant biliary complications. Clin Endosc 2017; 50 (05) 451-463
  • 38 DaVee T, Geevarghese SK, Slaughter JC, Yachimski PS. Refractory anastomotic bile leaks after orthotopic liver transplantation are associated with hepatic artery disease. Gastrointest Endosc 2017; 85 (05) 984-992
  • 39 Shuhart MC, Kowdley KV, McVicar JP. , et al. Predictors of bile leaks after T-tube removal in orthotopic liver transplant recipients. Liver Transpl Surg 1998; 4 (01) 62-70
  • 40 Sendino O, Fernández-Simon A, Law R. , et al. Endoscopic management of bile leaks after liver transplantation: an analysis of two high-volume transplant centers. United European Gastroenterol J 2018; 6 (01) 89-96
  • 41 Parlak E, Koksal AS, Eminler AT, Toka B, Uslan MI. Treatment of biliary stricture after live donor liver transplantation with combined metal and plastic stent insertion: a feasibility and safety study. Transplantation 2017; 101 (08) 1852-1858
  • 42 Park TY, Lee SK, Nam K. , et al. Spontaneous hemobilia after liver transplantation: frequency, risk factors, and outcome of endoscopic management. J Gastroenterol Hepatol 2017; 32 (03) 583-588
  • 43 Goenka MK, Harwani Y, Rai V, Goenka U. Fully covered self-expandable metal biliary stent for hemobilia caused by portal biliopathy. Gastrointest Endosc 2014; 80 (06) 1175
  • 44 Torres V, Martinez N, Lee G. , et al. How do we manage post-OLT redundant bile duct?. World J Gastroenterol 2013; 19 (16) 2501-2506
  • 45 Canete JJ, Aidlen JT, Uknis ME, Cicalese L. Images of interest. Hepatobiliary and pancreatic: biliary cast syndrome. J Gastroenterol Hepatol 2005; 20 (05) 791
  • 46 Barton P, Steininger R, Maier A, Mühlbacher F, Lechner G. Biliary sludge after liver transplantation: 2. Treatment with interventional techniques versus surgery and/or oral chemolysis. AJR Am J Roentgenol 1995; 164 (04) 865-869
  • 47 Gor NV, Levy RM, Ahn J, Kogan D, Dodson SF, Cohen SM. Biliary cast syndrome following liver transplantation: predictive factors and clinical outcomes. Liver Transpl 2008; 14 (10) 1466-1472
  • 48 Zhu XD, Shen ZY, Chen XG, Zang YJ. Pathotyping and clinical manifestations of biliary cast syndrome in patients after an orthotopic liver transplant. Exp Clin Transplant 2013; 11 (02) 142-149
  • 49 Hüsing A, Cicinnati VR, Beckebaum S, Wilms C, Schmidt HH, Kabar I. Endoscopic ultrasound: valuable tool for diagnosis of biliary complications in liver transplant recipients?. Surg Endosc 2015; 29 (06) 1433-1438
  • 50 Balderramo D, Sendino O, Miquel R. , et al. Prospective evaluation of single-operator peroral cholangioscopy in liver transplant recipients requiring an evaluation of the biliary tract. Liver Transpl 2013; 19 (02) 199-206
  • 51 Hüsing-Kabar A, Heinzow HS, Schmidt HH. , et al. Single-operator cholangioscopy for biliary complications in liver transplant recipients. World J Gastroenterol 2017; 23 (22) 4064-4071
  • 52 Wright H, Sharma S, Gurakar A, Sebastian A, Kohli V, Jabbour N. Management of biliary stricture guided by the Spyglass Direct Visualization System in a liver transplant recipient: an innovative approach. Gastrointest Endosc 2008; 67 (07) 1201-1203
  • 53 Franzini T, Moura R, Rodela G. , et al. A novel approach in benign biliary stricture - balloon dilation combined with cholangioscopy-guided steroid injection. Endoscopy 2015; 47 (Suppl. 01) E571-E572
  • 54 Raghavapuram S, Girotra M, Robertson JD, Pandey T, Tharian B. Successful management of ischemic cholangiopathy after failed endoscopic/percutaneous interventions, facilitated by digital cholangioscopy. Gastrointest Endosc 2016; 84 (06) 1053-1054
  • 55 Takao S, Matsuo Y, Shinchi H, Nakajima S, Aikou T, Iseji T, Yamanouchi E. Magnetic compression anastomosis for benign obstruction of the common bile duct. Endoscopy 2001; 33 (11) 988-990
  • 56 Ersoz G, Tekin F, Bozkaya H. , et al. Magnetic compression anastomosis for patients with a disconnected bile duct after living-donor related liver transplantation: a pilot study. Endoscopy 2016; 48 (07) 652-656
  • 57 Itoi T, Kasuya K, Sofuni A. , et al. Magnetic compression anastomosis for biliary obstruction: review and experience at Tokyo Medical University Hospital. J Hepatobiliary Pancreat Sci 2011; 18 (03) 357-365
  • 58 Jang SI, Kim JH, Won JY. , et al. Magnetic compression anastomosis is useful in biliary anastomotic strictures after living donor liver transplantation. Gastrointest Endosc 2011; 74 (05) 1040-1048
  • 59 Muraoka N, Uematsu H, Yamanouchi E. , et al. Yamanouchi magnetic compression anastomosis for bilioenteric anastomotic stricture after living-donor liver transplantation. J Vasc Interv Radiol 2005; 16 (09) 1263-1267
  • 60 Yazumi S, Yoshimoto T, Hisatsune H. , et al. Endoscopic treatment of biliary complications after right-lobe living-donor liver transplantation with duct-to-duct biliary anastomosis. J Hepatobiliary Pancreat Surg 2006; 13 (06) 502-510
  • 61 Gómez CM, Dumonceau JM, Marcolongo M. , et al. Endoscopic management of biliary complications after adult living-donor versus deceased-donor liver transplantation. Transplantation 2009; 88 (11) 1280-1285
  • 62 Chang JH, Lee IS, Choi JY. , et al. Biliary stricture after adult right-lobe living-donor liver transplantation with duct-to-duct anastomosis: long-term outcome and its related factors after endoscopic treatment. Gut Liver 2010; 4 (02) 226-233
  • 63 Hsieh TH, Mekeel KL, Crowell MD. , et al. Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy. Gastrointest Endosc 2013; 77 (01) 47-54
  • 64 Ranjan P, Bansal RK, Mehta N. , et al. Endoscopic management of post-liver transplant billiary complications: a prospective study from tertiary centre in India. Indian J Gastroenterol 2016; 35 (01) 48-54
  • 65 Rao HB, Prakash A, Sudhindran S, Venu RP. Biliary strictures complicating living donor liver transplantation: problems, novel insights and solutions. World J Gastroenterol 2018; 24 (19) 2061-2072
  • 66 Erdogan MA, Harputluoglu MM. Endoscopic treatment of biliary complications in left lobe living donor liver transplantation. Ther Clin Risk Manag 2018; 14: 2051-2056
  • 67 Rao HB, Ahamed H, Panicker S, Sudhindran S, Venu RP. Endoscopic therapy for biliary strictures complicating living donor liver transplantation: factors predicting better outcome. World J Gastrointest Pathophysiol 2017; 8 (02) 77-86
  • 68 Wadhawan M, Kumar A, Gupta S. , et al. Post-transplant biliary complications: an analysis from a predominantly living donor liver transplant center. J Gastroenterol Hepatol 2013; 28 (06) 1056-1060