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Semin Reprod Med 2019; 37(02): 093-104
DOI: 10.1055/s-0039-3400956
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Kisspeptin and Prolactin

David R. Grattan
1   Centre for Neuroendocrinology and Department of Anatomy, University of Otago, Dunedin, New Zealand
2   Maurice Wilkins Centre for Molecular Biodiscovery, Auckland, New Zealand
,
Raphael E. Szawka
3   Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
› Author Affiliations
Further Information

Publication History

Publication Date:
17 December 2019 (online)

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Abstract

The relationship between elevated prolactin and infertility has been known for a long time, but the specific mechanism by which prolactin inhibited reproduction had been uncertain. The discovery of kisspeptin has provided novel insights into how prolactin might cause infertility, with extensive evidence that elevated prolactin inhibits secretion of kisspeptin, resulting in hypogonadotropic hypogonadism, and infertility. More recent data suggest that a converse relationship might also exist, with evidence that kisspeptin influences prolactin secretion. This brief review will examine the relationship between kisspeptin and prolactin from each of these two perspectives: the well-characterized inhibitory effect of prolactin on kisspeptin neurons and the more recent concept that kisspeptin neurons are involved in the control of prolactin secretion.

Keywords

arcuate nucleus - KNDy - prolactin receptor - infertility - tuberoinfundibular dopamine neurons
 

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