Semin Reprod Med 2019; 37(04): 191-196
DOI: 10.1055/s-0039-3400964
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Phoenixin and Its Role in Reproductive Hormone Release

Sophie A. Clarke
1  Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
,
Waljit S. Dhillo
1  Section of Endocrinology and Investigative Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
23 January 2020 (online)

Abstract

Phoenixin is novel neuropeptide, recently identified following the description of a peptide sequence highly conserved across several animal species, including humans, cows, and pigs. Expressed both centrally in the hypothalamus and arcuate nucleus and peripherally in cardiac and gastrointestinal tissue, it appears to modulate reproductive hormone secretion in a gonadotrophin-releasing hormone–dependent manner and may also influence anxiety and memory. While there remains much to be described regarding its signaling, this review assesses the currently available literature in both animal and human studies to summarize our understanding of the physiological role of this novel neuropeptide, and its function in reproductive hormone release.