Endoscopy 2020; 52(S 01): S256
DOI: 10.1055/s-0040-1704801
ESGE Days 2020 ePoster presentations
Thursday, April 23, 2020 09:00 – 17:00 Clinical endoscopic practice ePoster area
© Georg Thieme Verlag KG Stuttgart · New York

INCREASING PREVALENCE OF ANXIETY AND DEPRESSION DISORDERS AFTER DIAGNOSIS OF CHRONIC PANCREATITIS: A 5 YEAR UNITED STATES POPULATION BASED STUDY

M Alkhayyat
1   Cleveland Clinic Foundation, Internal Medicine, Cleveland, U S A
,
MA Saleh
2   Cleveland Clinic Foundation, Gastroenterology, Hepatology and Nutrition, Cleveland, U S A
,
M Abureesh
3   Staten Island University Hospital, Internal Medicine, New York City, U S A
,
G Khoudari
4   Cleveland Clinic Foundation, Hospital Medicine, Cleveland, U S A
,
E Mansoor
5   University Hospital Cleveland Medical Center, Gastroenterology, Hepatology and Nutrition, Cleveland, U S A
,
C Roberto Simons-Linares
2   Cleveland Clinic Foundation, Gastroenterology, Hepatology and Nutrition, Cleveland, U S A
,
T Stevens
2   Cleveland Clinic Foundation, Gastroenterology, Hepatology and Nutrition, Cleveland, U S A
,
P Chahal
2   Cleveland Clinic Foundation, Gastroenterology, Hepatology and Nutrition, Cleveland, U S A
› Author Affiliations
Further Information

Publication History

Publication Date:
23 April 2020 (online)

Also available at
 

Aims Few studies have shown an increased risk of certain psychiatric conditions as well as substance abuse disorders in CP, however; these were limited by sample size. Using a large database, we sought to describe the epidemiology and risk association of several psychiatric diseases in patients with CP.

Tab. 1

Risk of anxiety, depressive disorders in chronic pancreatitis patients using univariate analysis

Anxiety

Depression

Age 18-65

1.72 (CI: 1.66–1.78)

1.55 (CI: 1.50–1.60)

Females

1.90 (CI: 1.84–1.96)

1.80 (CI: 1.75–1.86)

Caucasian

1.84 (CI: 1.77–1.91)

1.40 (CI: 1.35–1.44)

Methods A commercial database (Explorys Inc, Cleveland, OH, USA), an aggregate of electronic health record data from 26 US healthcare systems was surveyed. After excluding patients under 18 years old, a cohort of patients with a Systematized Nomenclature of Medicine-Clinical Terms of CP between 2014–2019 was identified. Within this cohort, the prevalence rates of anxiety and depressive disorders were calculated. Age-, race-, gender-, comorbidities-based distributions were described.

Results Of the 30,276,810 individuals in the database, 67,260 patients had a diagnosis of CP (0.22%). When compared to patients with no history of CP, patients with CP were more likely to develop anxiety [OR: 6.94; CI: 6.85–7.04, P < 0.0001] and depression [OR: 5.09; CI: 5.01–5.17, P < 0.0001]. Patients with CP and psychiatric conditions were more likely to be young adults (18–64 years old), females, Caucasians (Table 1). Patients are more likely to be smokers, with history of alcohol and substance abuse, personality disorder and had higher rate of suicidal ideation.

Conclusions In this large 5 year follow up population based study, we found patients with CP were at higher risk of developing several psychiatric conditions including anxiety and depression. Multidisciplinary care including appropriate recognition and management of their psychiatric disease burden is warranted.