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CC BY-NC-ND 4.0 · SynOpen 2020; 04(04): 107-115
DOI: 10.1055/s-0040-1705981
DOI: 10.1055/s-0040-1705981
review
Challenging Atroposelective C–H Arylation
Authors
Abstract
Atropisomeric molecules are privileged scaffolds, not only as ligands for asymmetric synthesis, but also as biologically active products and advanced materials. Although very attractive from a sustainability viewpoint, the direct construction of the stereogenic axis through asymmetric C–H arylation is very challenging and consequently only a few examples have been reported. This short review summarizes these very recent results on the atropo-enantio or diastereoselective synthesis of atropisomeric (hetero)biaryl molecules; transformations during which the Ar–Ar atropisomeric axis is formed during the C–H activation process.
1 Introduction
2 Atropo-enantioselective Intermolecular Pd-Catalyzed C–H Arylation of Thiophene Derivatives
3 Atropodiastereoselective Intermolecular Pd-Catalyzed C–H Arylation towards Terphenyl Scaffolds Bearing Two Atropisomeric Axes
4 Atropo-enantioselective Intramolecular Pd-Catalyzed C–H Arylation towards Atropisomeric Benzodiazepinones
5 Atropo-enantioselective Intermolecular Pd-Catalyzed C–H Arylation of Heteroarenes
6 Rh-Catalyzed Atropo-enantioselective C–H Arylation of Diazonaphthoquinones
7 Conclusion
Publikationsverlauf
Eingereicht: 28. September 2020
Angenommen nach Revision: 22. Oktober 2020
Artikel online veröffentlicht:
24. November 2020
© 2020. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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