Synlett 2020; 31(19): 1907-1912
DOI: 10.1055/s-0040-1707281
cluster
Integrated Synthesis Using Continuous-Flow Technologies

Photochemical Flow Oximation of Alkanes

Oliver M. Griffiths
a  Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK   Email: i.r.baxendale@durham.ac.uk
b  Department of Chemistry, Cambridge University, South Road, Cambridge, Cambridgeshire, CB2 1EW, UK
,
Michele Ruggeri
a  Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK   Email: i.r.baxendale@durham.ac.uk
,
Ian R. Baxendale
a  Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK   Email: i.r.baxendale@durham.ac.uk
› Author Affiliations


Abstract

The nitrosation of several alkanes using tert-butyl nitrite has been performed in flow showing a remarkable reduction in the reaction time compared with batch processing. Due to the necessity for large excesses of the alkane component a continuous recycling process was devised for the preparation of larger quantities of material.

Supporting Information



Publication History

Received: 24 July 2020

Accepted after revision: 19 August 2020

Publication Date:
21 September 2020 (online)

© 2020. Thieme. All rights reserved

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