J Pediatr Genet 2020; 09(02): 077-086
DOI: 10.1055/s-0040-1708521
Review Article
Georg Thieme Verlag KG Stuttgart · New York

HLA Polymorphisms and Food Allergy Predisposition

Maria Kostara
1   Department of Paediatrics, Ioannina University Hospital, Ioannina, Greece
Vasiliki Chondrou
2   Laboratory of Biology, School of Science and Technology, Hellenic Open University, Patras, Greece
Argyro Sgourou
2   Laboratory of Biology, School of Science and Technology, Hellenic Open University, Patras, Greece
Konstantinos Douros
3   Allergology and Pulmonology Unit, 3rd Pediatric Department, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece
Sophia Tsabouri
4   Department of Paediatrics, Child Health Department, School of Medicine, University of Ioannina, Ioannina, Greece
› Author Affiliations
Further Information

Publication History

14 October 2019

31 December 2019

Publication Date:
01 April 2020 (online)


Food allergy (FA) is a growing health problem that affects ∼8% of the children worldwide. Although the prevalence of FA is increasing, the underlying genetic mechanisms responsible for the onset of this immune disorder are not yet clarified. Genetic factors seem to play a leading role in the development of FA, though interaction with environmental factors cannot be excluded. The broader network of genetic loci mediating the risk of this complex disorder remains to be identified. The human leucocyte antigen (HLA) has been associated with various immune disorders, including FA. This review aims to unravel the potential associations between HLA gene functions and the manifestation and outcome of FA disorders. Exploring new aspects of FA development with the perspective to improve our understanding of the multifaceted etiology and the complex biological mechanisms involved in FA is essential.

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