Clin Colon Rectal Surg 2020; 33(05): 268-278
DOI: 10.1055/s-0040-1713744
Review Article

Multivisceral Resection of Advanced Pelvic Tumors: From Planning to Implementation

R. Mirnezami
1   Department of Colorectal Surgery, Royal Free Hospital, Hampstead, London
,
A. Mirnezami
2   Division of Cancer Sciences, Cancer Research UK Centre, University of Southampton, Southampton, United Kingdom
3   Southampton Complex Cancer and Exenterative Unit, University Hospital Southampton, Southampton, United Kingdom
› Author Affiliations
Funding The authors did not receive any financial support for this manuscript.

Abstract

Pelvic exenteration involves radical multivisceral resection for locally advanced and recurrent pelvic tumors. Advances in tumor staging, oncological therapies, preoperative patient optimization, surgical techniques, and critical care medicine have permitted the safe expansion of pelvic exenterative surgery at specialist units. It is now understood that in carefully selected patients, 5-year survival can exceed 60% following pelvic exenteration, and that very low mortality figures and an optimum postexenteration quality of life are possible. In the present review, we provide a contemporary summary of the current state of the art in pelvic exenterative surgery following all key phases of the treatment pipeline from patient staging and tumor assessment, to treatment planning and surgery.



Publication History

Article published online:
18 September 2020

Thieme Medical Publishers
333 Seventh Avenue, New York, NY 10001, USA.

 
  • References

  • 1 Brunschwig A. Complete excision of pelvic viscera for advanced carcinoma; a one-stage abdominoperineal operation with end colostomy and bilateral ureteral implantation into the colon above the colostomy. Cancer 1948; 1 (02) 177-183
  • 2 Harris CA, Solomon MJ, Heriot AG. , et al. The outcomes and patterns of treatment failure after surgery for locally recurrent rectal cancer. Ann Surg 2016; 264 (02) 323-329
  • 3 Nielsen MB, Rasmussen PC, Lindegaard JC, Laurberg S. A 10-year experience of total pelvic exenteration for primary advanced and locally recurrent rectal cancer based on a prospective database. Colorectal Dis 2012; 14 (09) 1076-1083
  • 4 Ferenschild FT, Vermaas M, Verhoef C. , et al. Total pelvic exenteration for primary and recurrent malignancies. World J Surg 2009; 33 (07) 1502-1508
  • 5 Beyond TME Collaborative. Consensus statement on the multidisciplinary management of patients with recurrent and primary rectal cancer beyond total mesorectal excision planes. Br J Surg 2013; 100 (08) E1-E33
  • 6 Dresen RC, Kusters M, Daniels-Gooszen AW. , et al. Absence of tumor invasion into pelvic structures in locally recurrent rectal cancer: prediction with preoperative MR imaging. Radiology 2010; 256 (01) 143-150
  • 7 Georgiou PA, Tekkis PP, Constantinides VA. , et al. Diagnostic accuracy and value of magnetic resonance imaging (MRI) in planning exenterative pelvic surgery for advanced colorectal cancer. Eur J Cancer 2013; 49 (01) 72-81
  • 8 Chew MH, Brown WE, Masya L, Harrison JD, Myers E, Solomon MJ. Clinical, MRI, and PET-CT criteria used by surgeons to determine suitability for pelvic exenteration surgery for recurrent rectal cancers: a Delphi study. Dis Colon Rectum 2013; 56 (06) 717-725
  • 9 Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg 2011; 253 (05) 890-899
  • 10 Hain E, Maggiori L, Manceau G, Mongin C, Prost À la Denise J, Panis Y. Oncological impact of anastomotic leakage after laparoscopic mesorectal excision. Br J Surg 2017; 104 (03) 288-295
  • 11 Lu ZR, Rajendran N, Lynch AC, Heriot AG, Warrier SK. Anastomotic leaks after restorative resections for rectal cancer compromise cancer outcomes and survival. Dis Colon Rectum 2016; 59 (03) 236-244
  • 12 Arnaboldi P, Santoro L, Mazzocco K, Oliveri S, Maggioni A, Pravettoni G. The paradox of pelvic exenteration: the interaction of clinical and psychological variables. Int J Gynecol Cancer 2015; 25 (08) 1534-1540
  • 13 Bhome R, Bullock M, Lee G. , et al. Pelvic sidewall dissection and resection in exenterative cancer surgery: 7-year surgical outcomes. Association of Coloproctology of Great Britain and Ireland (ACPGBI); 2018
  • 14 PelvEx Collaborative. Surgical and survival outcomes following pelvic exenteration for locally advanced primary rectal cancer: results from an international collaboration. Ann Surg 2019; 269 (02) 315-321
  • 15 Koh CE, Badgery-Parker T, Salkeld G, Young JM, Heriot AG, Solomon MJ. Cost-effectiveness of pelvic exenteration for locally advanced malignancy. Br J Surg 2016; 103 (11) 1548-1556
  • 16 Young JM, Badgery-Parker T, Masya LM. , et al. Quality of life and other patient-reported outcomes following exenteration for pelvic malignancy. Br J Surg 2014; 101 (03) 277-287
  • 17 Steffens D, Beckenkamp PR, Hancock M, Solomon M, Young J. Preoperative exercise halves the postoperative complication rate in patients with lung cancer: a systematic review of the effect of exercise on complications, length of stay and quality of life in patients with cancer. Br J Sports Med 2018; 52 (05) 344
  • 18 The Association of Coloproctology of Great Britain and Ireland. Accessed on June 10, 2020 at: ACPGBI IMPACT Initiative - Improving Management of Patients with Advanced Colorectal Tumours. 2017 https://www.acpgbi.org.uk/content/uploads/2017/02/IMPACT.pdf
  • 19 Rangarajan K, Bhome R, Bateman N. , et al. Pelvic exenteration with en bloc resection of the pelvic sidewall and intraoperative electron beam radiotherapy with Mobetron® for locally advanced rectal cancer. Tech Coloproctol 2017; 21 (06) 493-495
  • 20 Brady JT, Crawshaw BP, Murrell B. , et al. Influence of intraoperative radiation therapy on locally advanced and recurrent colorectal tumors: a 16-year experience. Am J Surg 2017; 213 (03) 586-589
  • 21 Mirnezami R, Chang GJ, Das P. , et al. Intraoperative radiotherapy in colorectal cancer: systematic review and meta-analysis of techniques, long-term outcomes, and complications. Surg Oncol 2013; 22 (01) 22-35