Semin Liver Dis 2021; 41(02): 109-116
DOI: 10.1055/s-0040-1716343
Review Article

Alcohol Use Disorder and Hepatitis C Prevention and Care in People Who Inject Drugs: The State of Play

Fabienne Marcellin
1  Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France
,
Antoine Jaquet
2  Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France
3  Inserm, ISPED, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France
,
Jeffrey V. Lazarus
4  Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain
,
Patricia Molina
5  Department of Physiology and Alcohol and Drug Abuse Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana
,
Patrizia Carrieri
1  Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques & Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France
› Author Affiliations
Funding F.M. and P.C. were supported by the French National Agency for Research on AIDS and Viral Hepatitis (Agence Nationale de Recherches sur le Sida et les hépatites virales, ANRS) and the French National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale, INSERM). A.J. was supported by a grant from the National Cancer Institute, the Eunice Kennedy Shriver National Institute of Child Health & Human Development, the National Institute of Allergy and Infectious Diseases, and the National Institute of Drug Abuse (grant no. 5U01AI069919). P.M. is supported by the National Institute of Health (NIH)/National Institute of Alcohol Abuse and Alcoholism (P60 AA009803). J.V.L. is supported by a Spanish Ministry of Science, Innovation, and Universities Miguel Servet grant (Instituto de Salud Carlos III/ESF, European Union [CP18/00074]) and further acknowledges support to ISGlobal from the Spanish Ministry of Science, Innovation, and Universities through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018–000806-S) and from the Government of Catalonia through the CERCA Program.

Abstract

Safe and effective treatment with direct-acting antivirals (DAAs) has ushered in an era in which hepatitis C virus (HCV) elimination, as set out by the World Health Organization, is possible. However, alcohol use disorder (AUD) has the potential to reduce the benefits of prevention interventions and reduce access to and continuity of HCV care in at-risk populations, such as people who inject drugs (PWID). We review the literature on the consequences of AUD on the effectiveness of HCV prevention and the cascade of care in PWID and provide recommendations for future research in the field of alcohol use and HCV.

Author Contributions

F. M. and P. C. drafted the manuscript. A. J., P. M., and J. V. L., contributed to the full manuscript and provided critical reviewing and suggestions throughout the different versions of this manuscript. All authors revised the manuscript and approved the final draft for submission.




Publication History

Publication Date:
26 August 2020 (online)

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA