Journal of Pediatric Neurology 2021; 19(03): 210-212
DOI: 10.1055/s-0040-1716393
Case Report

Neurological Manifestations of Novel Coronavirus Disease in a 2-Month-Old Infant: A Case Report

1   Pediatrics Department, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
,
1   Pediatrics Department, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
,
1   Pediatrics Department, Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran
,
2   Department of Pediatrics, Pediatric Gastroenterology and Hepatology Research Center, Tehran University of Medical Sciences, Bahrami Children's Hospital, Tehran, Iran
› Author Affiliations

Abstract

The main manifestations of novel coronavirus usually include fever and cough. Neurological manifestations have not been properly identified in children. A 65-day-old infant was hospitalized due to poor feeding, weakness, lethargy, and occasional cough. She suffered several seizures during her hospitalization. The brain computed tomography scan depicted a minor hemorrhage. Due to the exacerbation of her condition during hospital stay and the presence of respiratory symptoms in her parents, coronavirus disease was suspected. Reverse transcription–polymerase chain reaction (PCR) of coronavirus was positive for both: child and parents. In children with neurological manifestations such as lethargy, recurrent seizures, cerebral hemorrhage, and clinical evidence of respiratory symptoms in his/her relatives, PCR testing for coronavirus is recommended.



Publication History

Received: 23 June 2020

Accepted: 08 July 2020

Article published online:
02 September 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 McIntosh K, Hirsch MS, Bloom A. Coronavirus disease 2019 (COVID-19): Epidemiology, virology, and prevention. Accessed July 20, 2020 at: https://www.uptodate.com/contents/coronavirus-disease-2019-covid-19-epidemiology-virology-and-prevention
  • 2 Lu Q, Shi Y. Coronavirus disease (COVID-19) and neonate: what neonatologist need to know. J Med Virol 2020; 92 (06) 564-567
  • 3 Ludvigsson JF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr 2020; 109 (06) 1088-1095
  • 4 Lu X, Zhang L, Du H. et al; Chinese Pediatric Novel Coronavirus Study Team. SARS-CoV-2 infection in children. N Engl J Med 2020; 382 (17) 1663-1665
  • 5 Wang H-Y, Li X-L, Yan Z-R, Sun X-P, Han J, Zhang B-W. Potential neurological symptoms of COVID-19. Ther Adv Neurol Disorder 2020; 13 DOI: 1756286420917830.
  • 6 Filatov A, Sharma P, Hindi F, Espinosa PS. Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus 2020; 12 (03) e7352
  • 7 Andrew B. Janowski, David A. Hunstad. Viral Meningoencephalitis. In: Kliengman RM, Stanton BF, St Geme JW, Schor NF. eds. Nelson Text book of pediatrics. 20th ed.. Philadelphia: Saunders Elsevier; 2019: 3232-3234
  • 8 Panda PK, Sharawat IK. COVID-19 (SARS-CoV-2 infection) and children: pediatric neurologist's perspective. Indian J Pediatr 2020; 87 (07) 556-557
  • 9 Chacón-Aguilar R, Osorio-Cámara JM, Sanjurjo-Jimenez I, González-González C, López-Carnero J, Pérez-Moneo-Agapito B. COVID-19: fever syndrome and neurological symptoms in a neonate. An Pediatr (Engl Ed) 2020; 92 (06) 373-374
  • 10 Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J 2020; 39 (05) 355-368
  • 11 Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond) 2020; 52 (06) 427-429